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Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity [PDF]
CellsExcitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs ...
Ramiro D. Almeida +2 more
exaly +7 more sources
Glutamate-Induced Excitotoxicity in Parkinson's Disease: The Role of Glial Cells [PDF]
Journal of Pharmacological Sciences, 2020 Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate transmission efficiency depends on the correct functionality and expression of a plethora of receptors and transporters, located both on neurons and glial cells ...
Laura Civiero, Ludovica Iovino
exaly +6 more sources
An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats [PDF]
International Journal of Molecular Sciences, 2022 The neurotransmitter glutamate plays an essential role in excitatory neurotransmission; however, excessive amounts of glutamate lead to excitotoxicity, which is the most common pathogenic feature of numerous brain disorders. This study aimed to investigate the role of butyl 2-[2-(2-fluorophenyl)acetamido]benzoate (HFP034), a synthesized anthranilate ...
Tzu-Yu Lin, Su Jane Wang, Chiu Kuan-ming
exaly +7 more sources
Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity [PDF]
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Vsevolod Pinelis +2 more
exaly +4 more sources
CD3ζ-Mediated Signaling Protects Retinal Ganglion Cells in Glutamate Excitotoxicity of the Retina [PDF]
CellsExcessive levels of glutamate activity could potentially damage and kill neurons. Glutamate excitotoxicity is thought to play a critical role in many CNS and retinal diseases.
Rui Du, Ping Wang, Ning Tian
doaj +3 more sources
Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
doaj +3 more sources
A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system [PDF]
eLife, 2019 Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng +5 more
doaj +2 more sources
The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation
Frontiers in Molecular Neuroscience, 2023 Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine ...
Genhao Fan +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Wen Zhang +25 more
doaj +1 more source
Scientific Reports, 2021 Excess glutamate in the central nervous system may be a major cause of neurodegenerative diseases with gradual loss and dysfunction of neurons. Primary or secondary metabolites from medicinal plants and algae show potential for treatment of glutamate ...
Abeer Aldbass +7 more
doaj +1 more source