Results 1 to 10 of about 174,148 (299)

Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans

Scientific Reports, 2023
Achieving healthy aging and providing protection from aging-related diseases is a major global concern. Probiotics, are a safer and more natural alternative.
Kishoree K. Kumaree, Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Tewin Tencomnao, Chaiyavat Chaiyasut, Anchalee Prasansuklab   +6 more
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Sex differences in the role of AKAP12 in behavioral function of middle-aged mice

Biology of Sex Differences
A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules.
Hidehiro Ishikawa, Shintaro Kimura, Hajime Takase, Maximillian Borlongan, Norito Fukuda, Tomonori Hoshino, Gen Hamanaka, Ji Hyun Park, Akihiro Shindo, Kyu-Won Kim, Irwin H. Gelman, Josephine Lok, Eng H. Lo, Ken Arai   +13 more
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Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease: a pilot study

Scientific Reports
The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions.
Deborah Van Rossem, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, Veronique Michiels, Johan De Mey, Chris Baeken, Sebastiaan Engelborghs, Sara De Witte   +11 more
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Research on predictive model for tracheal tube sizes in adult double-lumen endotracheal intubation based on radiomics and artificial intelligence

Frontiers in Medicine
ObjectiveThis study aims to develop a predictive model for tracheal tube sizes in adult double-lumen endotracheal intubation using radiomics and artificial intelligence (AI) technologies to enhance the safety and efficiency of intubation procedures ...
Shaopeng Ming, Zhaoyu Li, Shu Yan, Wei Lan, Hongtao Liu, Yanzhuo Zhang   +5 more
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The Relevance and Implications of Monoclonal Antibody Therapies on Traumatic Brain Injury Pathologies

Biomedicines
Traumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction ...
Ping Wang, Starlyn Okada-Rising, Anke H. Scultetus, Zachary S. Bailey   +3 more
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Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system

Communications Biology
Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc.
Ester Licastro, Giuseppe Pignataro, Jeffrey J. Iliff, Yanxiao Xiang, Eng H. Lo, Kazuhide Hayakawa, Elga Esposito   +6 more
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Promoting Neuro‐Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels

Stem Cells Translational Medicine, 2019
Biomaterials provide novel platforms to deliver stem cell and growth factor therapies for central nervous system (CNS) repair. The majority of these approaches have focused on the promotion of neural progenitor cells and neurogenesis.
Su Jing Chan, Wanting Niu, Kazuhide Hayakawa, Gen Hamanaka, Xiaoying Wang, Pike See Cheah, Shuzhen Guo, Zhangyang Yu, Ken Arai, Magdy H. Selim, Motoichi Kurisawa, Myron Spector, Eng H. Lo   +12 more
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Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection
Background Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system. Silent information regulator sirtuin 1 (SIRT1) may deacetylate and suppress forkhead box O (FOXO) activities to promote neuronal survival.
Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu   +20 more
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5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

Acta Neuropathologica Communications, 2018
Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear.
Christian Klein, Guy Roussel, Susana Brun, Cristina Rusu, Christine Patte-Mensah, Michel Maitre, Ayikoe-Guy Mensah-Nyagan   +6 more
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Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells after Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

Cell Transplantation, 2016
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains.
Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai   +12 more
doaj   +1 more source