Results 1 to 10 of about 177,883 (410)
Biomedicines, 2022 The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes,
Rodrigo M. Maza +7 more
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Neuroprotective and neurorestorative therapy represent two major drug intervention strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation, angiogenesis, and neurogenesis are the main pathological processes that underlie ...
T. Zhu, Lei Wang, Liping Wang, Qi Wan
semanticscholar +1 more source
Pharmaceuticals, 2022 Nogo-A protein is a key myelin-associated inhibitor of axonal growth, regeneration, and plasticity in the central nervous system (CNS). Regulation of the Nogo-A/NgR1 pathway facilitates functional recovery and neural repair after spinal cord trauma and ...
Altea Soto +5 more
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Frontiers in Cellular Neuroscience, 2023 This analytical review summarizes literature data and our own research on HSP70-dependent mechanisms of neuroprotection and discusses potential pharmacological agents that can influence HSP70 expression to improve neurological outcomes and effective ...
I. Belenichev +3 more
semanticscholar +1 more source
Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection
International Journal of Molecular Sciences, 2023 Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy. Nervous cells accumulate oxidative damage, which is one of the factors that triggers and accelerates neurodegeneration.
Ignacio Moratilla-Rivera +3 more
semanticscholar +1 more source
Nature Communications, 2022 Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural ...
Wenlu Li +20 more
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Hypoxia and Brain Aging: Neurodegeneration or Neuroprotection?
Ageing Research Reviews, 2021 The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary disease.
Johannes Burtscher +3 more
semanticscholar +1 more source
O-GlcNAcylation is essential for therapeutic mitochondrial transplantation
Communications Medicine, 2023 Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular ...
Ji Hyun Park +11 more
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Data in Brief, 2020 This article provides information regarding the effect of four common high abundant protein (albumin and immunoglobulins (Ig)) depletion strategies upon serum proteomics datasets derived from normal, non-diseased rat or human serum. After tryptic digest,
Bharani Thangavelu +4 more
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Frontiers in Pharmacology, 2020 Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
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