Results 21 to 30 of about 128,007 (210)

Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury

, 2023
Military personnel are often victims of spinal cord injury resulting in lifetime disability and decrease in quality of life. However, no suitable therapeutic measures are still available to restore functional disability or arresting the ...
Buzoianu, Anca D.,, Sharma, Aruna,, Vicente Lafuente, José,, Tian, Z. Ryan,, Muresanu, Dafin F.,, Nozari, Ala,, Wiklund, Lars,, Sharma, Hari Shanker,, Huang, Hongyun,, Chen, Lin,, Feng, Lianyuan,, Sjöqvist, Per-Ove,   +11 more
core   +1 more source

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis

Journal of Neuroinflammation, 2019
Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are ...
Laurent Kremer, Omar Taleb, Nelly Boehm, Ayikoe Guy Mensah-Nyagan, Elisabeth Trifilieff, Jérôme de Seze, Susana Brun   +6 more
doaj   +1 more source

Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans

Scientific Reports, 2023
Achieving healthy aging and providing protection from aging-related diseases is a major global concern. Probiotics, are a safer and more natural alternative.
Kishoree K. Kumaree, Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Tewin Tencomnao, Chaiyavat Chaiyasut, Anchalee Prasansuklab   +6 more
doaj   +1 more source

Brain-to-cervical lymph node signaling after stroke

Nature Communications, 2019
Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate ...
Elga Esposito, Bum Ju Ahn, Jingfei Shi, Yoshihiko Nakamura, Ji Hyun Park, Emiri T. Mandeville, Zhanyang Yu, Su Jing Chan, Rakhi Desai, Ayumi Hayakawa, Xunming Ji, Eng H. Lo, Kazuhide Hayakawa   +12 more
doaj   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

VIP-induced neuroprotection of the developing brain. [PDF]

, 2011
International audienceExcitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits.
Sokolowska, Paulina, Passemard, Sandrine, Gressens, Pierre, Schwendimann, Leslie   +3 more
core   +5 more sources

Introductory Chapter: Concept of Neuroprotection - A New Perspective [PDF]

, 2019
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Yuen-Shan Ho, Ho, YS, Raymond Chuen-Chung Chang, Chang, RCC   +3 more
core   +1 more source

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C., ORDRONNEAU P, DEROSA J. T, CLARKE HALEY, E. JR, LEVIN, Bruce, THOMPSON J. L. P, PITTMAN J. C, DAVIS, Stephen, LEES, K. L, BROWN, D. L, FOR THE GAIN AMERICAS AND GAIN, DAVIS S, CAROLEI, ANTONIO, PITTMAN, John G, DEROSA, Janet T, ORDRONNEAU, Paul, SACCO R. L, INTERNATIONAL INVESTIGATORS, LEVIN B, HALEY E. C, SACCO, Ralph L, THOMPSON, John L. P, LEES, Kennedy R, BROWN, Devin L   +32 more
core   +1 more source

Investigating the Potential Role of Ecological Validity on Change-Detection Memory Tasks and Distractor Processing in Younger and Older Adults

Frontiers in Psychology, 2019
Cognitive performance is often found to be lower in older adults, especially when the task requires memory, executive functions, or selective attention.
Ulrike Rumpf, Ulrike Rumpf, Inga Menze, Inga Menze, Notger G. Müller, Notger G. Müller, Notger G. Müller, Marlen Schmicker   +7 more
doaj   +1 more source

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

Journal of Neuroinflammation, 2017
Background Microglial cultures comprise a critically important model system for investigating inflammatory mechanisms in almost all CNS disorders. Mild trypsinization and shaking are the two most commonly used methods to isolate primary microglia from ...
Li Lin, Rakhi Desai, Xiaoying Wang, Eng H. Lo, Changhong Xing   +4 more
doaj   +1 more source