Results 41 to 50 of about 128,007 (210)

Transcriptomic changes in oligodendrocyte lineage cells during the juvenile to adult transition in the mouse corpus callosum

Scientific Reports
The corpus callosum, a major white matter tract in the brain, undergoes age-related functional changes. To extend our investigation of age-related gene expression dynamics in the mouse corpus callosum, we compared RNA-seq data from 2 week-old and 12 week-
Tomonori Hoshino, Hajime Takase, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Emiri T. Mandeville, Josephine Lok, Eng H. Lo, Ken Arai   +8 more
doaj   +1 more source

Argon neuroprotection [PDF]

, 2010
Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury.
Sanders, Robert D, Ma, Daqing, Maze, Mervyn   +2 more
core   +1 more source

Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. [PDF]

, 2013
Delaying clinical disease onset would greatly reduce neurodegenerative disease burden, but the mechanisms influencing early preclinical progression are poorly understood.
Julien, Jean-Pierre, Gros-Louis, Francois, Leptien, Kerstin, Saxena, Smita, Caroni, Pico, Singh, Katyayani, Roselli, Francesco   +6 more
core   +2 more sources

Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells after Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

Cell Transplantation, 2016
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains.
Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai   +12 more
doaj   +1 more source

Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID

Neuroprotection, 2023
More than 670 million cases of coronavirus disease 2019 (COVID‐19) have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic.
Elizabeth Mendoza‐Portillo, Estefania Aleman‐Navarro, G. Aleph Prieto, Yvonne Rosenstein, Jose J. Lozano‐Nuevo, Araceli Perez‐Lopez   +5 more
doaj   +1 more source

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

Acta Neuropathologica Communications, 2018
Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear.
Christian Klein, Guy Roussel, Susana Brun, Cristina Rusu, Christine Patte-Mensah, Michel Maitre, Ayikoe-Guy Mensah-Nyagan   +6 more
doaj   +1 more source

Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

Neuroprotection, 2023
Hypoxia is increasingly recognized as an important physiological driving force. A specific transcriptional program, induced by a decrease in oxygen (O2) availability, for example, inspiratory hypoxia at high altitude, allows cells to adapt to lower O2 ...
Hannelore Ehrenreich, Max Gassmann, Luise Poustka, Martin Burtscher, Peter Hammermann, Anna‐Leena Sirén, Klaus‐Armin Nave, Kamilla Miskowiak   +7 more
doaj   +1 more source

Perinatal neuroprotection [PDF]

F1000Prime Reports, 2014
Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E., Jelin, Angie C., Thiet, Mari-Paule   +2 more
openaire   +2 more sources

Sex differences in the role of AKAP12 in behavioral function of middle-aged mice

Biology of Sex Differences
A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules.
Hidehiro Ishikawa, Shintaro Kimura, Hajime Takase, Maximillian Borlongan, Norito Fukuda, Tomonori Hoshino, Gen Hamanaka, Ji Hyun Park, Akihiro Shindo, Kyu-Won Kim, Irwin H. Gelman, Josephine Lok, Eng H. Lo, Ken Arai   +13 more
doaj   +1 more source

Research on predictive model for tracheal tube sizes in adult double-lumen endotracheal intubation based on radiomics and artificial intelligence

Frontiers in Medicine
ObjectiveThis study aims to develop a predictive model for tracheal tube sizes in adult double-lumen endotracheal intubation using radiomics and artificial intelligence (AI) technologies to enhance the safety and efficiency of intubation procedures ...
Shaopeng Ming, Zhaoyu Li, Shu Yan, Wei Lan, Hongtao Liu, Yanzhuo Zhang   +5 more
doaj   +1 more source