Results 41 to 50 of about 177,883 (410)

Brain-to-cervical lymph node signaling after stroke

Nature Communications, 2019
Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate ...
Elga Esposito, Bum Ju Ahn, Jingfei Shi, Yoshihiko Nakamura, Ji Hyun Park, Emiri T. Mandeville, Zhanyang Yu, Su Jing Chan, Rakhi Desai, Ayumi Hayakawa, Xunming Ji, Eng H. Lo, Kazuhide Hayakawa   +12 more
doaj   +1 more source

Neuroprotection in glaucoma

Indian Journal of Ophthalmology, 2011
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells and their axons. Recent evidence suggests that intraocular pressure (IOP) is only one of the many risk factors for this disease. Current treatment options for this disease have been limited to the reduction of IOP; however, it is clear now that the disease ...
Vasudevan Sushil, Gupta Viney, Crowston Jonathan   +2 more
openaire   +3 more sources

Neuroprotection in glaucoma

Indian Journal of Ophthalmology, 2022
Neuroprotective therapies in glaucoma may play a role in preventing ischemia and oxidative damage that results in apoptosis of retinal ganglion cells and optic nerve damage. Although intraocular pressure (IOP) is the only known modifiable risk factor for glaucoma, disease progression commonly occurs despite IOP control, suggesting that factors other ...
Vishwaraj, C R, Kavitha, Srinivasan, Venkatesh, Rengaraj, Shukla, Aakriti Garg, Chandran, Premanand, Tripathi, Shweta   +5 more
openaire   +2 more sources

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Neuroprotection
Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders. The glutamatergic system has emerged as a central player in the pathophysiology of various neurological disorders.
Jorge Y. Magdaleno Roman, C. Chapa González   +1 more
semanticscholar   +1 more source

Investigating the Potential Role of Ecological Validity on Change-Detection Memory Tasks and Distractor Processing in Younger and Older Adults

Frontiers in Psychology, 2019
Cognitive performance is often found to be lower in older adults, especially when the task requires memory, executive functions, or selective attention.
Ulrike Rumpf, Ulrike Rumpf, Inga Menze, Inga Menze, Notger G. Müller, Notger G. Müller, Notger G. Müller, Marlen Schmicker   +7 more
doaj   +1 more source

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C.   +9 more
core   +1 more source

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

Journal of Neuroinflammation, 2017
Background Microglial cultures comprise a critically important model system for investigating inflammatory mechanisms in almost all CNS disorders. Mild trypsinization and shaking are the two most commonly used methods to isolate primary microglia from ...
Li Lin, Rakhi Desai, Xiaoying Wang, Eng H. Lo, Changhong Xing   +4 more
doaj   +1 more source

Quercetin in Hypoxia-Induced Oxidative Stress: Novel Target for Neuroprotection

, 2012
Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging ...
Pandey, Anand Kumar, Sharma, Aruna,, Ranjana Patnaik, Dafin F. Muresanu, Anand Kumar Pandey, Sharma, Hari Shanker,, Hari Shanker Sharma, Patnaik, Ranjana, Aruna Sharma, Muresanu, Dafin F   +9 more
core   +1 more source

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research, 2015
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs).
Takakuni Maki, Yoko Takahashi, Nobukazu Miyamoto, Anna C. Liang, Masafumi Ihara, Eng H. Lo, Ken Arai   +6 more
doaj   +1 more source