Results 31 to 40 of about 118,682 (313)

Investigating the Potential Role of Ecological Validity on Change-Detection Memory Tasks and Distractor Processing in Younger and Older Adults

Frontiers in Psychology, 2019
Cognitive performance is often found to be lower in older adults, especially when the task requires memory, executive functions, or selective attention.
Ulrike Rumpf, Ulrike Rumpf, Inga Menze, Inga Menze, Notger G. Müller, Notger G. Müller, Notger G. Müller, Marlen Schmicker   +7 more
doaj   +1 more source

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin [PDF]

, 2020
Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in ...
Patnaik, Ranjana,, Sharma, Aruna,, Ala Nozari, Ranjana Patnaik, Dafin F. Muresanu, Tian, Z. Ryan,, Nozari, Ala,, Rudy J. Castellani, Hari Shanker Sharma, Aruna Sharma, Castellani, Rudy J.,, Lars Wiklund, Vicente Lafuente, Jose,, Z. Ryan Tian, Buzoianu, Anca D.,, Muresanu, Dafin F.,, Wiklund, Lars,, Sharma, Hari Shanker,, Anca D. Buzoianu, Sahib, Seaab,, José Vicente Lafuente, Seaab Sahib   +21 more
core   +1 more source

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons [PDF]

, 2021
Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypoxic ...
Zhu, L, Chow, O, Singh, A, Astbury, K, Chen, R, Rose, E, Jenkins, S   +6 more
core   +2 more sources

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C.   +9 more
core   +1 more source

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research, 2015
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs).
Takakuni Maki, Yoko Takahashi, Nobukazu Miyamoto, Anna C. Liang, Masafumi Ihara, Eng H. Lo, Ken Arai   +6 more
doaj   +1 more source

Neuroprotection by flavonoids [PDF]

Brazilian Journal of Medical and Biological Research, 2003
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and ...
Dajas, F., Rivera-Megret, F., Blasina, F., Arredondo, F., Abin-Carriquiry, J.A., Costa, G., Echeverry, C., Lafon, L., Heizen, H., Ferreira, M., Morquio, A.   +10 more
openaire   +5 more sources

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

Journal of Neuroinflammation, 2017
Background Microglial cultures comprise a critically important model system for investigating inflammatory mechanisms in almost all CNS disorders. Mild trypsinization and shaking are the two most commonly used methods to isolate primary microglia from ...
Li Lin, Rakhi Desai, Xiaoying Wang, Eng H. Lo, Changhong Xing   +4 more
doaj   +1 more source

Insulin Neuroprotection and the Mechanisms [PDF]

, 2015
Objective: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. Data Sources: The study is based on the data from PubMed.
Li-Yun Yu, Yu Pei
core   +1 more source

Liquid–liquid phase separation in synaptopathies

Neuroprotection, 2023
Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source