Results 31 to 40 of about 174,148 (299)

Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. [PDF]

, 2017
BackgroundTherapeutic hypothermia (TH) is the standard of care for neonates with hypoxic-ischemic encephalopathy, but it is not fully protective in the clinical setting.
Ferriero, Donna M, Koo, Elliot, Lee, Byong Sop, Sheldon, R Ann, Vexler, Zinaida S   +4 more
core   +2 more sources

Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury

Frontiers in Cellular Neuroscience, 2018
Autophagy is an essential process of cellular waist clearance that becomes altered following spinal cord injury (SCI). Details on these changes, including timing after injury, underlying mechanisms, and affected cells, remain controversial.
Teresa Muñoz-Galdeano, David Reigada, Ángela del Águila, Ángela del Águila, Irene Velez, Marcos J. Caballero-López, Rodrigo M. Maza, Manuel Nieto-Díaz   +7 more
doaj   +1 more source

Liquid–liquid phase separation in synaptopathies

Neuroprotection, 2023
Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
doaj   +1 more source

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]

, 2015
Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D, Bainbridge, A, Cady, E, Charles-Edwards, G, Deierl, A, Edwards, AD, Fagiolo, G, Franks, NP, Griffiths, J, Hajnal, J, Juszczak, E, Kapetanakis, B, Linsell, L, Maze, M, Omar, O, Robertson, NJ, Strohm, B, Tusor, N   +17 more
core   +2 more sources

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +9 more sources

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis

Journal of Neuroinflammation, 2019
Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are ...
Laurent Kremer, Omar Taleb, Nelly Boehm, Ayikoe Guy Mensah-Nyagan, Elisabeth Trifilieff, Jérôme de Seze, Susana Brun   +6 more
doaj   +1 more source

Brain-to-cervical lymph node signaling after stroke

Nature Communications, 2019
Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate ...
Elga Esposito, Bum Ju Ahn, Jingfei Shi, Yoshihiko Nakamura, Ji Hyun Park, Emiri T. Mandeville, Zhanyang Yu, Su Jing Chan, Rakhi Desai, Ayumi Hayakawa, Xunming Ji, Eng H. Lo, Kazuhide Hayakawa   +12 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Neuroprotection [PDF]

Neurotherapeutics, 2004
Preface.List of Contributors.PART I: NEUROLOGICAL DISORDERS-EPIDEMIOLOGY, CLINICAL OVERVIEW, AND MODEL SYSTEMS.1. Stroke (Andreas Meisel, Konstantin Prass, Tilo Wolf, Ulrich Dirnagl).Abstract.1.1 Introduction.1.2 The Penumbra Concept.1.3 Excitotoxicity.1.4 Oxygen Free Radicals.1.5 Tissue Acidosis.1.6 Peri-infarct Depolarizations.1.7 Inflammation.1.8 ...
  +4 more sources

Investigating the Potential Role of Ecological Validity on Change-Detection Memory Tasks and Distractor Processing in Younger and Older Adults

Frontiers in Psychology, 2019
Cognitive performance is often found to be lower in older adults, especially when the task requires memory, executive functions, or selective attention.
Ulrike Rumpf, Ulrike Rumpf, Inga Menze, Inga Menze, Notger G. Müller, Notger G. Müller, Notger G. Müller, Marlen Schmicker   +7 more
doaj   +1 more source