Results 31 to 40 of about 128,007 (210)

Quercetin in Hypoxia-Induced Oxidative Stress: Novel Target for Neuroprotection

, 2012
Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging ...
Pandey, Anand Kumar, Sharma, Aruna,, Ranjana Patnaik, Dafin F. Muresanu, Anand Kumar Pandey, Sharma, Hari Shanker,, Hari Shanker Sharma, Patnaik, Ranjana, Aruna Sharma, Muresanu, Dafin F   +9 more
core   +1 more source

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research, 2015
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs).
Takakuni Maki, Yoko Takahashi, Nobukazu Miyamoto, Anna C. Liang, Masafumi Ihara, Eng H. Lo, Ken Arai   +6 more
doaj   +1 more source

Neuroprotection in glaucoma [PDF]

Cell and Tissue Research, 2013
Glaucoma is a frequent eye disease in the elderly and the second leading cause of irreversible blindness both in developed and developing countries (Resnikoff et al. 2004). Presently, about 50 million people are blind from glaucoma worldwide, a number that has not significantly changed over the last decade (Resnikoff et al. 2004; Thylefors et al. 1995).
Ernst R, Tamm, Franz, Grehn, Norbert, Pfeiffer   +2 more
openaire   +2 more sources

Disruption of Sema3A/Plexin‐A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination

EMBO Molecular Medicine, 2019
Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions.
Fabien Binamé, Lucas D Pham‐Van, Caroline Spenlé, Valérie Jolivel, Dafni Birmpili, Lionel A Meyer, Laurent Jacob, Laurence Meyer, Ayikoé G Mensah‐Nyagan, Chrystelle Po, Michaël Van der Heyden, Guy Roussel, Dominique Bagnard   +12 more
doaj   +1 more source

Neuroprotection by flavonoids [PDF]

Brazilian Journal of Medical and Biological Research, 2003
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and ...
Dajas, F., Rivera-Megret, F., Blasina, F., Arredondo, F., Abin-Carriquiry, J.A., Costa, G., Echeverry, C., Lafon, L., Heizen, H., Ferreira, M., Morquio, A.   +10 more
openaire   +5 more sources

Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes

Scientific Reports
The COVID-19 pandemic caused by the SARS-CoV-2 virus has greatly affected global health. Emerging evidence suggests a complex interplay between Alzheimer’s disease (AD), diabetes (DM), and COVID-19.
Dicson Sheeja Malar, Kanika Verma, Mani Iyer Prasanth, Tewin Tencomnao, James Michael Brimson   +4 more
doaj   +1 more source

Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions

Antioxidants
Epigenetics defines changes in cell function without involving alterations in DNA sequence. Neuroepigenetics bridges neuroscience and epigenetics by regulating gene expression in the nervous system and its impact on brain function.
Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Clerance Su Yee Cheong, Kanika Verma, Tewin Tencomnao, James Michael Brimson, Anchalee Prasansuklab   +6 more
doaj   +1 more source

Study of red wine neuroprotection on astrocytes

, 2009
Phenolic composition of wine depends not only on the grape variety from which it is made, but on some external factors such as winemaking technology. Red wine possesses the most antioxidant effect because of its high polyphenolic content. The aim of this
Palomino Ruiz-Poveda, Olga María, Gómez-Serranillos Cuadrado, María Pilar, Martín, Sara, Ortega Hernández-Agero, María Teresa, Carretero Accame, María Emilia, Estrella, Isabel, Vacas, Visitación, Hernández, Teresa, Prodanov, Marín   +8 more
core   +1 more source

Neuroprotection and hypothermia in infants and children

, 2012
Brain injury is the leading cause of death in pediatric ICU. Current evidence supports the use of therapeutic hypothermia (TH) in unconscious patients after out-of-hospital cardiac arrest when the initial heart rhythm was ventricular fibrillation.
Cavaliere, Franco, De Luca, Daniele, Mancino, Aldo, Pietrini, Domenico, Piastra, Marco, Conti, Giorgio   +5 more
core   +1 more source

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons [PDF]

, 2021
Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypoxic ...
Zhu, L, Chow, O, Singh, A, Astbury, K, Chen, R, Rose, E, Jenkins, S   +6 more
core   +1 more source