Results 31 to 40 of about 177,883 (410)

Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury

open access: yes, 2023
Military personnel are often victims of spinal cord injury resulting in lifetime disability and decrease in quality of life. However, no suitable therapeutic measures are still available to restore functional disability or arresting the ...
Buzoianu, Anca D.,   +11 more
core   +1 more source

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

open access: yesStroke, 2020
Supplemental Digital Content is available in the text. Background and Purpose— Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral ischemia in rodents and to ...
Chen Wang   +16 more
semanticscholar   +1 more source

Neuroprotection by flavonoids [PDF]

open access: yesBrazilian Journal of Medical and Biological Research, 2003
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and ...
Dajas, F.   +10 more
openaire   +5 more sources

Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury

open access: yesFrontiers in Cellular Neuroscience, 2018
Autophagy is an essential process of cellular waist clearance that becomes altered following spinal cord injury (SCI). Details on these changes, including timing after injury, underlying mechanisms, and affected cells, remain controversial.
Teresa Muñoz-Galdeano   +7 more
doaj   +1 more source

Liquid–liquid phase separation in synaptopathies

open access: yesNeuroprotection, 2023
Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
doaj   +1 more source

Gamma Entrainment Binds Higher Order Brain Regions and Offers Neuroprotection

open access: yesNeuron, 2019
SUMMARY Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer’s disease. Recently, we showed that inducing gamma oscillations with visual stimulation (Gamma ENtrainment Using ...
Chinnakkaruppan Adaikkan   +11 more
semanticscholar   +1 more source

Progesterone and neuroprotection [PDF]

open access: yesHormones and Behavior, 2013
Numerous studies aimed at identifying the role of estrogen on the brain have used the ovariectomized rodent as the experimental model. And while estrogen intervention in these animals has, at least partially, restored cholinergic, neurotrophin and cognitive deficits seen in the ovariectomized animal, it is worth considering that the removal of the ...
Meharvan, Singh, Chang, Su
openaire   +2 more sources

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis

open access: yesJournal of Neuroinflammation, 2019
Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are ...
Laurent Kremer   +6 more
doaj   +1 more source

Introductory Chapter: Concept of Neuroprotection - A New Perspective [PDF]

open access: yes, 2019
published_or_final_versio
Yuen-Shan Ho   +3 more
core   +1 more source

Potential circadian effects in translational failure for neuroprotection

open access: yesNature, 2020
Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans1,2 may contribute to this failure in ...
E. Esposito   +12 more
semanticscholar   +1 more source

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