Results 11 to 20 of about 153,025 (224)
Molecular mechanisms of ischemia and glutamate excitotoxicity [PDF]
Life Sciences, 2023 Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs).
Diogo Neves +3 more
openaire +6 more sources
Nicorandil mitigates glutamate excitotoxicity in primary cultured neurons [PDF]
Medicine ScienceExcitotoxicity, caused by the excessive release of glutamate, leads to the activation of the apoptotic process, making it a crucial factor in age-related neurodegenerative diseases.
Muhammed Sait Ertugrul +6 more
doaj +2 more sources
NSC-34 motor neuron-like cells are unsuitable as experimental model for glutamate-mediated excitotoxicity [PDF]
Frontiers in Cellular Neuroscience, 2016 Glutamate-induced excitotoxicity is a major contributor to motor neuron degeneration in the pathogenesis of amyotrophic lateral sclerosis (ALS). The spinal cord X Neuroblastoma hybrid cell line (NSC-34) is often used as a bona fide cellular model to ...
Blandine eMadji Hounoum +16 more
doaj +2 more sources
Glutamate excitotoxicity in multiple sclerosis
Анналы клинической и экспериментальной неврологии, 2017 A comparative analysis of the level of neuroactive amino acidglutamate in the blood serum of 17 healthy individuals and 63patients with multiple sclerosis (MS), according to the course,stage and duration of the disease and disability, was performed.The ...
A. A. Ryazantseva +4 more
doaj +2 more sources
Phosphorylation Status of GluN2B-Ser1303 Under Glutamate-induced Excitotoxicity in Primary Cortical Neurons: An In Vitro Study [PDF]
Caspian Journal of Neurological Sciences, 2023 Background: Glutamate, an excitatory neurotransmitter, plays a pivotal role in cellular phenomena in neurons, like synaptic plasticity and excitotoxicity.
Ramya R Prabhu
doaj +1 more source
Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity. [PDF]
Membranes (Basel), 2022 It is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate the development of neurodegenerative diseases in humans.
Zgodova A +6 more
europepmc +2 more sources
Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy. [PDF]
Int J Mol Sci, 2022 Glutamate excitotoxicity induces neuronal cell death during epileptic seizures. Death-associated protein kinase 1 (DAPK1) expression is highly increased in the brains of epilepsy patients; however, the underlying mechanisms by which DAPK1 influences ...
Gan CL +13 more
europepmc +2 more sources
Quercetin’s Effects on Glutamate Cytotoxicity
Molecules, 2022 The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease ...
Kade Riche, Natalie R. Lenard
doaj +1 more source
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2020 Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss
Adam Armada-Moreira +24 more
doaj +1 more source
, 2022 Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Nan Pang (5181971) +8 more
core +1 more source