Results 41 to 50 of about 153,025 (224)
Protection from Glutamate-Induced Excitotoxicity by Memantine [PDF]
Annals of Biomedical Engineering, 2011 This study investigates whether the uncompetitive N-methyl-D-aspartic acid receptor antagonist, memantine, is able to protect dissociated cortical neurons from glutamate-induced excitotoxicity (GIE). Treatment with glutamate resulted in a significant loss of synchronization of neuronal activity as well as a significant increase in the duration of ...
Melinda K, Kutzing +2 more
openaire +2 more sources
Glutamate Excitotoxicity in the Cerebellum Mediated by IL-1β [PDF]
The Journal of Neuroscience, 2013 Multiple sclerosis (MS) is the prototypic inflammatory demyelinating disorder of the CNS. Symptoms of cerebellar dysfunction, such as tremors and ataxia, are relatively common in MS, but available treatment options are generally of limited value.
Alma Nazlie, Mohebiany +1 more
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Frontiers in Cellular Neuroscience, 2015 Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis +3 more
doaj +1 more source
Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells. [PDF]
Cell Mol Life Sci, 2020 International audienceWe investigated the role of autophagy, a controlled lysosomal degradation of cellular macromolecules and organelles, in glutamate excitotoxicity during nutrient deprivation in vitro.
Vucicevic L +11 more
europepmc +2 more sources
Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity [PDF]
, 2022 Parkinson's disease is associated with neuronal loss in the midbrain and the resulting development of dopamine-deficient states. At the later stages of the disease, increased neuronal death is also observed in other parts of the brain.
Berezhnov, A, Fedotova, E, Abramov, AY
core +1 more source
Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model
ASN Neuro, 2012 Glutamate excitotoxicity is a major pathogenic process implicated in many neurodegenerative conditions, including AD (Alzheimer's disease) and following traumatic brain injury.
Katherine A Hosie +4 more
doaj +1 more source
Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]
PLoS ONE, 2014 The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski +3 more
doaj +1 more source
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons [PDF]
, 2020 Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in consumer products.
Haug, Trude M +9 more
core +2 more sources
Changes in intracellular pH associated with glutamate excitotoxicity [PDF]
The Journal of Neuroscience, 1993 Excitotoxic neuronal injury is known to be associated with increases in cytosolic calcium ion concentrations. However, it is not known if perturbations in other intracellular ions are also associated with glutamate (GLU)-induced neuronal death. Accordingly, intracellular hydrogen ion concentrations were measured in cultured hippocampal neurons with the
Z, Hartley, J M, Dubinsky
openaire +2 more sources
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source