Results 31 to 40 of about 153,025 (224)
Glutamate Excitotoxicity and Neurodegeneration [PDF]
Journal of Molecular and Genetic Medicine, 2014 Glutamate plays crucial roles in the physiology of the central nervous system as it can control many functions such as memory, learning, cognitive, emotional, endocrine and other visceral functions. In addition, glutamate is the major excitatory neurotransmitter in the mammalian central nervous system.
openaire +1 more source
Inhibition of Mg2+ Extrusion Attenuates Glutamate Excitotoxicity in Cultured Rat Hippocampal Neurons. [PDF]
Nutrients, 2020 Magnesium plays important roles in the nervous system. An increase in the Mg2+ concentration in cerebrospinal fluid enhances neural functions, while Mg2+ deficiency is implicated in neuronal diseases in the central nervous system.
Shindo Y, Yamanaka R, Hotta K, Oka K.
europepmc +2 more sources
BMC Complementary Medicine and Therapies, 2023 Background Stroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate.
Rafael Short Ferreira +18 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
In vivo co-ordinated interactions between inhibitory systems to control glutamate mediated hippocampal excitability. [PDF]
, 2013 We present an overview of the long-term adaptation of hippocampal neurotransmission to cholinergic and GABAergic deafferentation caused by excitotoxic lesion of the medial septum.
Rodríguez Allué, Manuel José +3 more
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Ceftriaxone preserves glutamate transporters and prevents intermittent hypoxia-induced vulnerability to brain excitotoxic injury. [PDF]
PLoS ONE, 2014 Hypoxia alters cellular metabolism and although the effects of sustained hypoxia (SH) have been extensively studied, less is known about chronic intermittent hypoxia (IH), commonly associated with cardiovascular morbidity and stroke.
Rekha Jagadapillai +3 more
doaj +1 more source
Medroxyprogesterone acetate exacerbates glutamate excitotoxicity
Gynecological Endocrinology, 2006 We previously demonstrated that progesterone functions as a neuroprotective agent whereas medroxyprogesterone acetate (MPA; Provera) does not. Moreover, MPA antagonized the neuroprotective and neurotrophic outcomes induced by 17beta-estradiol (E2). Towards developing effective hormone therapies for protection against neurodegeneration, we sought to ...
Jon, Nilsen +2 more
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Cells, 2019 Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa Mahmoud +3 more
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Frontiers in Cellular Neuroscience, 2020 Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune ...
Haziq Kamal +8 more
doaj +1 more source
Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke. [PDF]
PLoS ONE, 2012 Glutamate excitotoxicity, metabolic rate and inflammatory response have been associated to the deleterious effects of temperature during the acute phase of stroke. So far, the association of temperature with these mechanisms has been studied individually.
Francisco Campos +9 more
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