Results 21 to 30 of about 153,025 (224)
Axonal degeneration induced by glutamate-excitotoxicity is mediated by necroptosis [PDF]
, 2018 Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma as well as degeneration of axons
Court, F. A. +11 more
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Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
Bezmiâlem Science, 2021 Objective:Glutamate is the major excitatory transmitter in the brain. The excessive glutamate will lead to excitotoxicity. Glutamate transporter-1 (GLT-1) is the major transporter that performs 95% of the glutamate clearance contributing to normal ...
Rabia UYARICI +2 more
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Research progress on the role of glutamate transporter in the pathogenesis of Parkinson's disease [PDF]
Jichu yixue yu linchuang, 2021 The excitotoxicity mediated by glutamate (Glu) is the main pathogenesis of Parkinson’s disease (PD), and the glutamate transporter is the key factor regulating the process of Glu excitotoxicity.
MA Li-fang, LIANG Jian-qing, HE Jian-cheng, SUN Xue, LIANG Peng
doaj
Bioenergetics and glutamate excitotoxicity
Progress in Neurobiology, 1996 Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems.
J G, Greene, J T, Greenamyre
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Life, 2022 Glutamate neurotransmission and metabolism are finely modulated by the retinal network, where the efficient processing of visual information is shaped by the differential distribution and composition of glutamate receptors and transporters.
Isabella Boccuni, Richard Fairless
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Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease
Frontiers in Neuroscience, 2020 Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang +10 more
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Cholesterol loss during glutamate‐mediated excitotoxicity [PDF]
The EMBO Journal, 2012 The deregulation of brain cholesterol metabolism is typical in acute neuronal injury (such as stroke, brain trauma and epileptic seizures) and chronic neurodegenerative diseases (Alzheimer's disease). Since both conditions are characterized by excessive stimulation of glutamate receptors, we have here investigated to which extent excitatory ...
Sodero AO +11 more
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Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown [PDF]
, 2021 Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate.
Filadi, Riccardo +15 more
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Various facets of excitotoxicity
Exploration of Neuroprotective Therapy, 2022 Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser +10 more
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Mitochondria and neuronal glutamate excitotoxicity
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 The role of mitochondria in the control of glutamate excitotoxicity is investigated. The response of cultured cerebellar granule cells to continuous glutamate exposure is characterised by a transient elevation in cytoplasmic free calcium concentration followed by decay to a plateau as NMDA receptors partially inactivate. After a variable latent period,
Nicholls, David G, Budd, Samantha L
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