Results 81 to 90 of about 79,124 (218)

MPTP-induced degeneration: interference with glutamatergic toxicity [PDF]

, 1994
Parkinson's disease (PD) is characterised by the progressive degeneration of nigrostriatal dopamine (DA) neurons resulting in the major symptoms of akinesia and rigidity.
Lange, Klaus W., Löschmann, P. A., Turski, L., Wachtel, H.   +3 more
core  

Immunohistochemical evaluation of aquaporin-4 and its correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 expressions in fatal traumatic brain injury [PDF]

, 2018
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Our understanding of its pathobiology has substantially increased.
Cantatore, Santina, Cipolloni, Luigi, Di Paolo, Marco, Fineschi, Vittorio, Frati, Alessandro, Frati, Paola, La Russa, Raffaele, Maiese, Aniello, Neri, Margherita, Santurro, Alessandro, Scopetti, Matteo, Sessa, Francesco, Turillazzi, Emanuela, Zamparese, Rosanna   +13 more
core   +2 more sources

Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis [PDF]

, 2018
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated
A Frati, AA Hyder, AM Palmer, AW Selassie, B Buller, B Roozenbeek, CJ Murray, D Thurman, DH Smith, DK Menon, DM Stein, DR Li, EM Graham, F Masson, F Tagliaferri, FE Sherriff, FM Barabas, FM Shahim, G Illerhaus, H Bayir, HA Kontos, I Humphreys, JB Redell, JB Redell, JB Redell, JF Geddes, JH Adams, JT Povlishock, JT Povlishock, K Blennow, K Dams-O’Connor, K Fukuda, K Sakai, KM O’Connell, L Tao, M Oehmichen, M Oehmichen, M Ogata, M Valiyaveettil, M Ziu, MA Ansari, MB Grosjean, N Stoicea, OG Bhalala, PR Turner, R Sandhir, RM Chesnut, S Griffiths-Jones, S Griffiths-Jones, S Schiavone, S Thornhill, S Yokobori, SK Kwon, T Frugier, T Strickland, TY Sun, V Pietro Di, VA Tyurin, W Peeters, WL Maxwell, WX Wang, X Ge, X Ge, Y Li, Y Zhang, Z Hu   +65 more
core   +3 more sources

Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease

Toxins, 2020
The carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) exerts a neuroprotective effect in neurodegenerative diseases via the activation of signaling pathways related to neurotrophins, and also through inhibiting apoptotic cell death ...
Mireia Herrando-Grabulosa, Caty Casas, Kevin Talbot, José Aguilera   +3 more
doaj   +1 more source

Spinal Cord Trauma: An Overview of Normal Structure and Function, Primary and Secondary Mechanisms of Injury, and Emerging Treatment Modalities [PDF]

, 2018
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within.
Morin, Daniel
core   +1 more source

Bioenergetics and glutamate excitotoxicity

Progress in Neurobiology, 1996
Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems.
J G, Greene, J T, Greenamyre
openaire   +2 more sources

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Excitotoxicity [PDF]

Cell Death & Differentiation, 1997
P, Nicotera, M, Leist
openaire   +2 more sources

The case for neuregulin-1 as a clinical treatment for stroke

Frontiers in Cellular Neuroscience
Ischemic stroke is the leading cause of serious long-term disability and the 5th leading cause of death in the United States. Revascularization of the occluded cerebral artery, either by thrombolysis or endovascular thrombectomy, is the only effective ...
Jessica M. Noll, Jessica M. Noll, Arya A. Sherafat, Gregory D. Ford, Byron D. Ford   +4 more
doaj   +1 more source

Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective

Frontiers in Neurology, 2018
Context/Objectives: Spinal cord injury (SCI) results in significant neuronal and glial cell death resulting in impaired neurological and motor function. Uncontrolled Ca2+ entry results in excitotoxicity and cell death.
Marianne Jacobsen, Kristen Lett, John Mark Barden, Gavin L. Simpson, Josef Buttigieg   +4 more
doaj   +1 more source