Results 81 to 90 of about 57,791 (292)
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
Methylxanthines, Seizures, and Excitotoxicity [PDF]
, 2010 Clinical evidence, in particular the wide use of theophylline as a bronchodilator, suggests that methylxanthines can cause seizures in patients without known underlying epilepsy. Theophylline is also known to be an added risk factor for seizure exacerbation in patients with epilepsy.
openaire +2 more sources
Epileptic Disorders, EarlyView.Abstract Background Temporal lobe epilepsy (TLE) and functional dissociative seizures (FDS) are distinct conditions that share overlapping clinical, neuropsychiatric, and biological features, including depressive symptoms, obesity‐related metabolic dysregulation, and alterations in systemic inflammatory markers.
Betül Merd +4 more
wiley +1 more source
A brief critique of excitotoxicity in amyotrophic lateral sclerosis
Academia BiologyThe excitotoxicity hypothesis has been significantly influential in amyotrophic lateral sclerosis (ALS) research for over thirty years but has seen limited clinical success.
Lorenzo Odierna
doaj +1 more source
, 2016 Ding-Siang Huang,1,* Hsuan-Yuan Lin,1,2,* Guey-Jen Lee-Chen,1 Hsiu-Mei Hsieh-Li,1 Chung-Hsin Wu,1 Jung-Yaw Lin1,21Department of Life Science, National Taiwan Normal University, 2Institute of Biochemistry and Molecular Biology, National Taiwan University,
Huang DS +5 more
core
Epilepsia, EarlyView.On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta +4 more
wiley +1 more source
Could calcitonin gene‐related peptide inhibitors prevent status epilepticus?
Epilepsia, EarlyView.Abstract Calcitonin gene‐related peptide (CGRP) inhibitors modulate pain and neuroinflammation, a recognized contributor to epileptogenesis and status epilepticus (SE). We examined the association between CGRP inhibitor use and SE hospitalization in epilepsy patients with comorbid migraine.
Michael Nsaka +6 more
wiley +1 more source
The case for neuregulin-1 as a clinical treatment for stroke
Frontiers in Cellular NeuroscienceIschemic stroke is the leading cause of serious long-term disability and the 5th leading cause of death in the United States. Revascularization of the occluded cerebral artery, either by thrombolysis or endovascular thrombectomy, is the only effective ...
Jessica M. Noll +4 more
doaj +1 more source
Frontiers in Neurology, 2018 Context/Objectives: Spinal cord injury (SCI) results in significant neuronal and glial cell death resulting in impaired neurological and motor function. Uncontrolled Ca2+ entry results in excitotoxicity and cell death.
Marianne Jacobsen +4 more
doaj +1 more source