Results 101 to 110 of about 80,747 (355)
Interdisciplinary Medicine, EarlyView.Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi +18 more
wiley +1 more source
, 2016 Ding-Siang Huang,1,* Hsuan-Yuan Lin,1,2,* Guey-Jen Lee-Chen,1 Hsiu-Mei Hsieh-Li,1 Chung-Hsin Wu,1 Jung-Yaw Lin1,21Department of Life Science, National Taiwan Normal University, 2Institute of Biochemistry and Molecular Biology, National Taiwan University,
Huang DS +5 more
core
Journal of Applied Toxicology, EarlyView.ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac +2 more
wiley +1 more source
Excitotoxicity and Axon Degeneration
, 2014 Excitotoxicity has been implicated as a key pathogenic pathway in a number of neurodegenerative diseases and conditions including Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, brain trauma, and stroke. While acute excitotoxicity
James Vickers (14751775) +1 more
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Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
The metabolic response to excitotoxicity - lessons from single-cell imaging.
, 2015 Excitotoxicity is a pathological process implicated in neuronal death during ischaemia, traumatic brain injuries and neurodegenerative diseases. Excitotoxicity is caused by excess levels of glutamate and over-activation of NMDA or calcium-permeable AMPA ...
Jochen Prehn (7895672) +1 more
core +1 more source
Journal of Neuroscience, 1992 In Alzheimer's disease (AD), abnormal accumulations of beta-amyloid are present in the brain and degenerating neurons exhibit cytoskeletal aberrations (neurofibrillary tangles).
M. Mattson +5 more
semanticscholar +1 more source
Movement Disorders, EarlyView.Abstract Background Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS). Objectives We examined the association of gray matter volume loss in PDP patients with brain expression of the genes coding for CB1 (cannabinoid type 1) and CB2 ...
Sara Pisani +3 more
wiley +1 more source
The case for neuregulin-1 as a clinical treatment for stroke
Frontiers in Cellular NeuroscienceIschemic stroke is the leading cause of serious long-term disability and the 5th leading cause of death in the United States. Revascularization of the occluded cerebral artery, either by thrombolysis or endovascular thrombectomy, is the only effective ...
Jessica M. Noll +4 more
doaj +1 more source