Results 101 to 110 of about 79,124 (218)

Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]

, 2019
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason, Davis, Bethany, Fitzpatrick, James A.J., Gantz, Jay A, Hirose, Keiko, Kallogjeri, Dorina, Kim, Kyunghee X, Li, Song-Zhe, Ohlemiller, Kevin K, Payne, Shelby, Rutherford, Mark A, V-Ghaffari, Babak, Yang-Hood, Aizhen   +12 more
core   +1 more source

Slow in Motion but Smart in Learning and Memory: Behavioral Changes in Adult NR3A Knockout Mice [PDF]

, 2011
The expression of NMDA receptor subunit NR3A is high in the neonatal brain but low in adults. However, its functional role in the adult brain is obscure.
Ling Wei, Mingke Song, Osama Mohamad, Shan Ping Yu   +3 more
core   +1 more source

Advancements and challenges in amyotrophic lateral sclerosis

Frontiers in Neuroscience
Amyotrophic lateral sclerosis (ALS) continues to pose a significant challenge due to the disease complexity and heterogeneous manifestations. Despite recent drug approvals, there remains a critical need for the development of more effective therapies ...
David Bradford, Kathleen E. Rodgers
doaj   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Temporal Changes in Mitochondria-Centric Excitotoxic Responses Following Severe Penetrating Traumatic Brain Injury

Biomedicines
Background/Objectives: Traumatic brain injury (TBI) remains a significant and urgent medical concern for the US military. TBI triggers excitotoxic responses immediately, involving mitochondrial dysfunction characterized by loss of calcium (Ca2+) cycling,
Hiren R. Modi, Sudeep Musyaju, Anke H. Scultetus, Jignesh D. Pandya   +3 more
doaj   +1 more source

Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PDF]

Brain Commun
Silva-Hucha S, Hernández RG, Baena-López D, Fernández de Sevilla ME, Paradas C, Morcuende S.   +5 more
europepmc   +1 more source

Polarity of varicosity initiation in central neuron mechanosensation [PDF]

, 2017
Akhmanova, Amack, Andrieux, Baas, Barry, Barry, Barsukova, Benfenati, Bentley, Betz, Beyder, Bosc, Bu, Campàs, Caterina, Chen Gu, Cho, Christensen, Chung, Cosens, Couégnas, David Brody, Debanne, DeFord, Delmas, Deloulme, Eastwood, Elkin, Engler, Fournet, Franze, Gao, Gardner, Gibson, Gilmour, Grevesse, Gu, Gu, Gu, Gu, Gu, Guillaud, Harrington, Hasbani, Hemphill, Iwata, Jukkola, Jukkola, Kanayama, Kang, Koleske, Laurer, Lefèvre, Liedtke, Liedtke, Ligon, Lu, Luo, Margolis, Montell, Morris, Namba, Nikić, Peter Jukkola, Pirollet, Qian Wang, Reeves, Richard, Rishal, Ryskamp, Serrano, Shepherd, Shibasaki, Shitaka, Smith, Staal, Strotmann, Sánchez, Tang-Schomer, Thomas Esparza, Tseng, van Beuningen, Van Essen, Venkatachalam, Wang, Wang, Xu, Xu, Yang, Yi Zhao, Yuanzheng Gu, Zheng, Ziv, Árnadóttir   +93 more
core   +2 more sources

NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway. [PDF]

PLoS One
Li Y, Li D, Geng C, Wei R, Duan Y.
europepmc   +1 more source

Glutamatergic Neurotransmission Disruption as a Pathomechanism of Brain Damage in Disorders of Amino Acid and Organic Acid Metabolism: Insights from Animal and Cellular Studies. [PDF]

Neurochem Res
Marcuzzo MB, Benati MPDV, Souza DO, Wajner M, Leipnitz G.   +4 more
europepmc   +1 more source

Anesthetic Neuroprotection Based on Ion-Channel-Modulating Drugs in Acute Traumatic Brain Injury. [PDF]

Cureus
Zamora EL, Alvarez Ramirez D, Soto Cordero CA, Chavarría R, Montoya S.   +4 more
europepmc   +1 more source