Results 121 to 130 of about 80,747 (355)

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

Severe traumatic brain injury: a modern understanding of the pathophysiological mechanisms of brain damage

Medičnì Perspektivi
The review article presents modern ideas about the molecular and cellular mechanisms of brain damage in severe traumatic brain injury (TBI). The aim of the study is to analyze the pathophysiological links of primary and secondary brain damage in severe ...
A.V. Tsarev, V.I. Zhilyuk, A.E. Lievykh, A.V. Bukreieva   +3 more
doaj   +1 more source

Apoptosis in retinal excitotoxicity.

, 1997
Kwong Man Kwong.Thesis (M.Phil.)--Chinese University of Hong Kong, 1997.Includes bibliographical references (leaves 83-99).TABLE OF CONTENTS --- p.iACKNOWLEDGEMENTS --- p.viLIST OF FIGURES --- p.viiLIST OF ABBREVIATIONS --- p.ixChapter I ...

core  

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

Mediators of Inflammation, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
G. Olmos, J. Lladó
semanticscholar   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease [PDF]

, 2009
Rona K. Graham, Mahmoud A. Pouladi, Prasad Joshi, Ge Lu, Yu Deng, Nanping Wu, Bryan E. Figueroa, Martina Metzler, Véronique M. André, Elizabeth Slow, Lynn A. Raymond, Robert M. Friedlander, Michael S. Levine, Blair R. Leavitt, Michael R. Hayden   +14 more
openalex   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Glutamate Excitotoxicity: A Key Secondary Injury Mechanism of Traumatic Brain Injury and Spinal Cord Injury

Frontiers in Bioscience-Landmark
Glutamate excitotoxicity is one of the key factors in the pathophysiology of the secondary injury cascade following traumatic brain injury (TBI) and spinal cord injury (SCI). These neurotraumatic conditions remain major causes of long-term disability and
Jiamei Hou, Kelena Klippel, Prodip Bose
doaj   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Molecular mechanisms of calcium-dependent excitotoxicity

, 2000
Excitotoxicity is thought to be a major mechanism contributing to neurodegeneration during central nervous system ischemia, trauma, and other neurological disorders.
Tymianski, Michael, Sattler, Rita
core   +1 more source