Results 131 to 140 of about 80,747 (355)
Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ [PDF]
, 2016 Elena Hernández‐Encinas +6 more
openalex +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim +5 more
wiley +1 more source
Protection Provided by Cyclosporin A against Excitotoxic Neuronal Death Is Genotype Dependent [PDF]
, 2003 Julia Belen Santos, P. Elyse Schauwecker
openalex +1 more source
Alcohol Intake and Parkinson Symptoms Following Diagnosis
Movement Disorders, EarlyView.
Laurie K. Mischley, Joshua Farahnik
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen +2 more
wiley +1 more source
Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity
, 2000 Excitatory synaptic activity governs excitotoxicity and modulates the distribution of NMDA receptors (NMDARs) among synaptic and extrasynaptic sites of central neurons.
Wei-Yang Lu +9 more
core +1 more source
Cell Proliferation, EarlyView.Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon +6 more
wiley +1 more source
299 PRE-084, A Sigma-1 Receptor Ligand, Protects Against Excitotoxic Perinatal Brain Injury in Newborn Mice [PDF]
, 2012 Elke Griesmaier +8 more
openalex +1 more source