Results 111 to 120 of about 80,747 (355)

Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective

Frontiers in Neurology, 2018
Context/Objectives: Spinal cord injury (SCI) results in significant neuronal and glial cell death resulting in impaired neurological and motor function. Uncontrolled Ca2+ entry results in excitotoxicity and cell death.
Marianne Jacobsen, Kristen Lett, John Mark Barden, Gavin L. Simpson, Josef Buttigieg   +4 more
doaj   +1 more source

TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.

Frontiers in Cellular Neuroscience, 2016
Embryonic stem cells (ESC) are pluripotent and thus can differentiate into every cell type present in the body. Directed differentiation into motor neurons has been described for pluripotent cells. Although neurotrophic factors promote neuronal survival,
Daniel Édgar Cortés, Daniel Édgar Cortés, Yolanda Robledo-Arratia, Ricardo Hernández-Martínez, Itzel Escobedo-Avila, Jose Bargas, Ivan Velasco, Ivan Velasco   +7 more
doaj   +1 more source

Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders

Nature Neuroscience, 2016
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown.
Wen Zhang, Lifeng Zhang, Bo Liang, D. Schroeder, Zhong-wei Zhang, G. Cox, Yun Li, Da-Ting Lin   +7 more
semanticscholar   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Excitotoxicity in vitro by NR2A− and NR2B−containing NMDA receptors

, 2007
Excitotoxicity, exacerbating acute brain damage from brain trauma or stroke, is mediated in part by excessive Ca2+−influx from prolonged NMDA receptor activation.
von Engelhardt, J., Fuchs, Elke, Seeburg, Peter H., Monyer, Hannah, Pawlak, Verena, Pawlak, V., Fuchs, E., Köhr, Georg, Köhr, G., von Engelhardt, Jakob, Seeburg, P., Coserea, I., Monyer, H., Coserea, Irina   +13 more
core   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Methylxanthines, Seizures, and Excitotoxicity [PDF]

, 2010
Clinical evidence, in particular the wide use of theophylline as a bronchodilator, suggests that methylxanthines can cause seizures in patients without known underlying epilepsy. Theophylline is also known to be an added risk factor for seizure exacerbation in patients with epilepsy.
openaire   +2 more sources

Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation

PLoS ONE, 2017
Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions in the brain. PRL exerts a neuroprotective effect against excitotoxicity produced by glutamate (Glu) or kainic acid in both in vitro and
N. A. Rivero-Segura, E. Flores-Soto, Selene García de la Cadena, I. Coronado-Mares, J. C. Gómez-Verjan, Diana G. Ferreira, E. A. Cabrera-Reyes, Luísa V. Lopes, L. Massieu, M. Cerbón   +9 more
semanticscholar   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

Cells, 2014
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
doaj   +1 more source