Results 151 to 160 of about 80,747 (355)

Advancements and challenges in amyotrophic lateral sclerosis

Frontiers in Neuroscience
Amyotrophic lateral sclerosis (ALS) continues to pose a significant challenge due to the disease complexity and heterogeneous manifestations. Despite recent drug approvals, there remains a critical need for the development of more effective therapies ...
David Bradford, Kathleen E. Rodgers
doaj   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Neurosteroid effects on intracellular calcium and excitotoxicity [PDF]

, 2019
NMDA receptors belong to the family of ionotropic glutamate receptors, and are involved in synaptic plasticity, learning and memory. However, overactivation by the agonist glutamate can lead to neuronal death - excitotoxicity.
Naimová, Žaneta
core  

Parallel pathways of glutamate and ATP-mediated excitotoxicity cause significant neural cell death during ischaemia: potential for novel neuroprotective strategies

, 2013
Philipp Vermehren, Robert Fern
openalex   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Temporal Changes in Mitochondria-Centric Excitotoxic Responses Following Severe Penetrating Traumatic Brain Injury

Biomedicines
Background/Objectives: Traumatic brain injury (TBI) remains a significant and urgent medical concern for the US military. TBI triggers excitotoxic responses immediately, involving mitochondrial dysfunction characterized by loss of calcium (Ca2+) cycling,
Hiren R. Modi, Sudeep Musyaju, Anke H. Scultetus, Jignesh D. Pandya   +3 more
doaj   +1 more source

disseminating brain damage following NMDA‐induced excitotoxicity

, 2002
The ability of cannabinoid CB, receptors to influence glutamatergic excitatory neurotransmission has fueled interest in how these receptors and their endogenous ligands may interact in conditions of excitotoxic insults.
Henrik H. Hansen, Ramos, J.A., Julián Romero, Romero, J., Luis Miguel García‐Segura, Hansen, H.H., Javier Fernández‐Ruiz, Fernández-Ruiz, J., Azcoitia, I., Harald S. Hansen, José Antonio Ramos, Hansen, Harald S., Sebastián Pons, García-Segura, L.M., Pons, S., Iñigo Azcoitia   +15 more
core   +1 more source

The cardiac glycoside ouabain potentiates excitotoxic injury of adult neurons in rat hippocampus

, 1995
Michael Brines, Amos O. Daré, Nihal C. de Lanerolle   +2 more
openalex   +1 more source

Amacrine cell inputs to OFF midget ganglion cells in macaque retina

The Journal of Physiology, EarlyView.
Abstract figure legend The goal of this study was to explain the findings from physiological studies that OFF midget ganglion cells had larger receptive field centers than expected from their dendritic field diameters. First, we confirmed that OFF mRGCs (OFF MGC) receive input from diffuse bipolar cells (DB) as well as OFF midget bipolar cells (FMB ...
David W. Marshak, Andrea S. Bordt, Emma R. Yang, Joel N. Yearick, Marcus Mazzaferri, James A. Kuchenbecker, Judith Mosinger Ogilvie, Sara S. Patterson, Jay Neitz   +8 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources