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Mitochondrial Ca<sup>2+</sup> Signaling at the Tripartite Synapse: A Unifying Framework for Glutamate Homeostasis, Metabolic Coupling, and Network Vulnerability. [PDF]
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Neurology, 1996
This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
P N, Leigh, B S, Meldrum
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This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
P N, Leigh, B S, Meldrum
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Excitotoxicity and mitochondria
Biochemical Society Symposia, 1999Excitotoxicity is the process whereby a massive glutamate release in the central nervous system in response to ischaemia or related trauma leads to the delayed, predominantly necrotic death of neurons. Excitotoxicity is also implicated in a variety of slow neurodegenerative disorders.
D G, Nicholls +3 more
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CELL DAMAGE/EXCITOTOXICITY | Excitotoxicity and Neurodegenerative Disease
2009Excitotoxicity is an established mechanism of neuronal killing. Many neurodegenerative diseases, including epilepsy, have implicated excitotoxicity in their pathogenesis. Studies characterizing excitotoxic mechanisms in these diseases have subsequently focused on studying aspects of glutamate transporters and/or receptors.
Tannenberg, R. K., Dodd, P. R.
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Excitotoxicity and neurodegenerative diseases
Current Opinion in Neurology, 1995Glutamate is an excitatory neurotransmitter in the mammalian central nervous system and a neurotoxin (excitotoxin) that has the potential to destroy neurones by activation of ionotropic receptors. In contrast to the well documented role of glutamate in the pathogenesis of neuronal degeneration resulting from hypoxia/ischaemia, hypoglycaemia, status ...
C, Ikonomidou, L, Turski
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European Journal of Pharmacology, 2002
Excitotoxicity results from prolonged activation of glutamate receptors expressed by cells in the central nervous system (CNS). This cell death mechanism was first discovered in retinal ganglion cells and subsequently in brain neurons. In addition, it has been recently observed that CNS glial cells can also undergo excitotoxicity.
Carlos, Matute +3 more
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Excitotoxicity results from prolonged activation of glutamate receptors expressed by cells in the central nervous system (CNS). This cell death mechanism was first discovered in retinal ganglion cells and subsequently in brain neurons. In addition, it has been recently observed that CNS glial cells can also undergo excitotoxicity.
Carlos, Matute +3 more
openaire +2 more sources