Results 161 to 170 of about 12,017 (197)

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

Targeting Microglial HDAC5 Suppresses NLRP3 Inflammation via NF‐κB Deacetylation to Alleviate Ischemic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Cerebral ischemia/reperfusion induced HDAC5 upregulation in microglia. Elevated HDAC5 promoted NLRP3‐mediated neuroinflammation via NF‐κB p65 deacetylation. RGD‐EV:miR‐9‐5p delivery suppressed microglial HDAC5 and attenuated ischemic brain injury. ABSTRACT Objective Histone deacetylases are implicated in ischemic stroke, yet the role of HDAC5 remains ...
Ru‐Yu Liang, Jia‐Qi Zhang, Tian‐Yi Jiang, Li‐Qing Tao, Wen She, Zhou‐Na Sun, Cui Qi, Jun Gao   +7 more
wiley   +1 more source

RAF1 Promotes Gstt1‐Mediated Ferroptosis by Promoting KDM1A Recruitment to Facilitate Pilocarpine‐Induced Acute Seizure‐Associated Neuronal Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In the hippocampus of mice with pilocarpine‐induced acute seizures and in glutamate‐treated neuronal cell lines, the mRNA and protein levels of RAF1 were significantly increased. RAF1 interacts with the KDM1A and recruits it to the promoter of Gstt1, thereby inhibiting the transcription of Gstt1.
Tiantian Lu, Yonghong Feng, Xiuling Chen, Liyan Shen, Min Liu, Yanping Jia   +5 more
wiley   +1 more source

Compound Ciwujia Granules Attenuate Stress‐Induced Anxiety‐ and Depression‐Like Behaviors via Inhibition of TNF‐α‐Associated Neuroinflammation in the dmPFC

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
By restoring glutamatergic neuronal activity, suppressing TNF‐related inflammatory signaling pathway, and reducing microglial overactivation in the dmPFC, CWJ ameliorated stress‐induced behavioral abnormalities. ABSTRACT Aims Compound Ciwujia Granules (CWJ) have shown antidepressant‐like effects, but the neural and molecular mechanisms underlying these
Fei Tian, Yi Li, Mengyu Dai, Yihan Guo, Bingbing Liao, Yingdan Zhang, Xin Gong, Lanying Liu, Dongdong Shi, Zhen Wang   +9 more
wiley   +1 more source

Apoptin‐Derived Peptide Alleviates Temporal Lobe Epilepsy (TLE) by Limiting Neuronal Ca2+ Overload Through the HSPA1A–AP2B1 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Epileptogenic stress upregulates HSPA1A, impairs AP2B1 O‐GlcNAcylation and stability, and promotes GluA2 loss‐associated CP‐AMPAR formation and Ca2+ overload. B9 attenuates epileptogenesis by targeting the HSPA1A–AP2B1 axis, restoring AP2B1 O‐GlcNAcylation and stability, preserving GluA2‐associated AMPAR regulation, and reducing pathological Ca2 ...
Zixiao Tan, Qilong Zhai, Jingwen Cui, Xiaoying Gao, Xingan Liu, Zhijie Fan, Yu Liu, Jiahang Sun   +7 more
wiley   +1 more source

Interferon‐γ Mitigates Oxaliplatin‐Induced Neurotoxicity: Analogies With Connexin 43

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
IFN‐γ mitigates oxaliplatin‐induced neurotoxicity by reducing neuroinflammation and neuronal excitability, suggesting a protective mechanism involving Cx43 modulation and potential therapeutic value in chemotherapy‐induced neurotoxicity. ABSTRACT Aims Chemotherapy‐induced neuropathy is a major side effect of platinum‐based drugs such as oxaliplatin ...
Alessandra Toti, Valentina Ferrara, Elena Lucarini, Laura Micheli, Clara Ciampi, Francesco Margiotta, Daniel Venturi, Carmen Parisio, Elisabetta Gerace, Lorenzo Curti, Alessio Masi, Tommaso Mello, Guido Mannaioni, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +14 more
wiley   +1 more source

Sex‐Specific Effects of Dexmedetomidine on Brain Microvascular Endothelial Cell Function After Traumatic Brain Injury in Juvenile Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Traumatic brain injury (TBI) induces acute, sex‐specific activation of endoplasmic reticulum (ER) stress, inflammatory signaling, and ferroptotic mechanisms within brain microvascular endothelial cells (BMECs). Administration of dexmedetomidine (DEX) produces both sex‐dependent and sex‐independent modulatory effects on BMECs, prominently suppressing ...
Yara Mashal, Jie Fan, Tia Atoui, Zahrah Naseer, Sara Moughni, Iman Tawil, Zhi Zhang   +6 more
wiley   +1 more source

Deanna Protocol Ameliorates the Deficits in Human iPSC‐Cortical Neurons Carrying Familial Alzheimer's Mutation

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Human iPSC‐derived cortical neurons carrying a PSEN1 Alzheimer's mutation exhibit mitochondrial dysfunction, hyperexcitability, amyloid and tau pathology, and impaired synaptic plasticity. The Deanna Protocol, an anaplerotic metabolic supplement, rescues these deficits, supporting energy restoration as a viable therapeutic strategy for Alzheimer's ...
Leticia Keler Soares, Gaurav Srivastava, Camden Dwelle, Brianna Waggoner, Vince Tedone, James J. Hickman, Xiufang Guo   +6 more
wiley   +1 more source

PANoptosis In Microglia and Neurons Following Traumatic CNS Injury: A Systematic Review of Pathological Features and Therapeutic Implications

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Following traumatic CNS injury, PANoptosis is activated in microglia and neurons, with microglia–neuron crosstalk serving as a key feature of this process. The PANoptosome sensors ZBP1 and NLRP12, together with the adaptor ASC, activate downstream executioner proteins to drive PANoptosis.
Zhusheng Feng, Yingnan Fan, Tianshu Du, Peipei Huang, Yuqin Ye, Junjie Li   +5 more
wiley   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source