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SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells

open access: yesHuman and Experimental Toxicology, 2020
Excitotoxicity is the presence of excessive glutamate, which is normally taken up by glutamate transporters on astrocytes. Glutamate transporter 1 (GLT-1) is the major transporter on glia cells clearing more than 90% of the glutamate.
Gizem Donmez Yalcin
exaly   +2 more sources

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Frontiers in Cellular Neuroscience, 2020
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Excitotoxicity is Required for Induction of Oxidative Stress and Apoptosis in Mouse Striatum by the Mitochondrial Toxin, 3-Nitropropionic Acid

Journal of Cerebral Blood Flow and Metabolism, 2000
Gyung W Kim   +2 more
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Frontiers in Neuroscience, 2020
Dennis W Choi
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Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-α

Apoptosis: an International Journal on Programmed Cell Death, 2017
Zheng-Hong Qin, Rong Han
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The Role of Excitotoxicity in Neurodegenerative Disease

Pharmacology & Therapeutics, 1999
Adam Doble
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