Results 181 to 190 of about 80,747 (355)

A lifespan staging model of basal forebrain cholinergic vulnerability

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age‐ and Alzheimer's disease‐related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (the why) and the temporal sequence (the how) have yet to be fully resolved.
Hayley R. C. Shanks, Sherry Chen, Kate M. Onuska, Taylor W. Schmitz   +3 more
wiley   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo

, 1997
Eliezer Masliah, C. Westland, Edward Rockenstein, Carmela R. Abraham, Margaret Mallory, I Veinberg, Elizabeth Sheldon, Lennart Mucke   +7 more
openalex   +1 more source

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source

Potential Neuroprotective Effects of Docosahexaenoic Acid on Glutamate-Induced Neurotoxicity: A Systematic Review of Pre-Clinical Studies. [PDF]

Nutrients
Rusleen MHR, Mansor NI, Hamid AA, Mohd Nor NH, Mohamed Z.   +4 more
europepmc   +1 more source

Protective Effect of Apelin-13 on D-Glutamic Acid-Induced Excitotoxicity in Sh-Sy5y Cell Line: An In-Vitro Study

Kadriye Yağmur Oruç, Gökhan Ağtürk, Aykut Oruç, Karolin Yanar, Hakkı Oktay Seymen   +4 more
openalex   +1 more source

Ex Vivo and In Vivo Neuroprotection Induced by Argon When Given after an Excitotoxic or Ischemic Insult

, 2012
Hélène David, Benoît Haelewyn, Mickaël Degoulet, D Colomb, Jean‐Jacques Risso, Jacques H. Abraini   +5 more
openalex   +2 more sources

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

The Use of Primary Spiral Ganglion Cells in Studying Glutamate Receptor Function and Excitotoxicity in the Cochlea. [PDF]

Cells
Polikarpov EV, Smolyarchuk EA, Fisenko AP, Bakaeva ZV.   +3 more
europepmc   +1 more source

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons

, 2012
Kevin H. J. Park, Ge Lu, Jing Fan, Lynn A. Raymond, Blair R. Leavitt   +4 more
openalex   +2 more sources