Results 191 to 200 of about 80,747 (355)

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Correction: Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection. [PDF]

Cell Death Dis
Esteban-Ortega GM, Torres-Campos E, Díaz-Guerra M.   +2 more
europepmc   +1 more source

Investigating the Effect of SER-1 in a Caenorhabditis elegans Model of Glutamate Excitotoxicity

, 2016
vi, 30 p.Excitotoxicity, the underlying mechanism common to all neurodegenerative diseases, is the pathology of necrotic effects caused by the prolonged activation of excitatory neurotransmitter receptors in the central nervous system.
Alzouhayli, Suma
core  

Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists

, 2012
Antonio H. Martins, Janaina Alves, Dinely Pérez, M. Carrasco, Wilmarie Torres-Rivera, Vesna A. Eterović, P.A. Ferchmin, Henning Ulrich   +7 more
openalex   +2 more sources

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PDF]

Brain Commun
Silva-Hucha S, Hernández RG, Baena-López D, Fernández de Sevilla ME, Paradas C, Morcuende S.   +5 more
europepmc   +1 more source

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

, 2021
Edward Pajarillo, Alexis Digman, Ivan Nyarko‐Danquah, Deok‐Soo Son, Karam F. A. Soliman, Michael Aschner, Eun-Sook Lee   +6 more
openalex   +1 more source

Toosendanin Alleviates Cerebral Ischemia/Reperfusion Injury via Inhibiting Neural Ferroptosis Through Lipid Metabolic Reprogramming in MCAO Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Post‐stroke administration of TSN significantly reduced infarct volume, neuroinflammation, and improved functional recovery of MCAO mice. TSN alleviated neural oxidative stress, lipid peroxidation, and ferroptosis in MCAO mice. TSN modulated the infiltration of immune cells in MCAO mice in vivo and T cell differentiation in vitro.
Xinyun Li, Zhiyong Zhao, Jingting Zhao, Xiangming Ye, Zhenfei Xiong, Jiejin Zhao   +5 more
wiley   +1 more source

NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway. [PDF]

PLoS One
Li Y, Li D, Geng C, Wei R, Duan Y.
europepmc   +1 more source

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

, 2010
Marta Vieira, Joana Fernandes, Ana Burgeiro, Gareth M. Thomas, Richard L. Huganir, Carlos B. Duarte, Ana Luı́sa Carvalho, Armanda E. Santos   +7 more
openalex   +2 more sources