Results 31 to 40 of about 80,747 (355)

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells.

Journal of Pharmacological Sciences, 2020
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate transmission efficiency depends on the correct functionality and expression of a plethora of receptors and transporters, located both on neurons and glial cells ...
L. Iovino, M. Tremblay, L. Civiero
semanticscholar   +1 more source

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Journal of Neuroinflammation, 2021
During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microglia, and possibly other ...
Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, K. Kambas, L. Iliopoulou, Roman Fischer, R. Kontermann, M. Denis, G. Kollias, H. Lassmann, L. Probert   +11 more
semanticscholar   +1 more source

Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective

Frontiers in Neuroscience, 2021
Excitotoxicity has been implicated in many neurological disorders and is a leading cause of oxidative stress and neuroinflammation in the nervous system.
Kathleen F. Holton
doaj   +1 more source

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity

Molecular Pain, 2017
N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear.
Yu Wu, Changwan Chen, Qian Yang, Mingfei Jiao, Shuang Qiu   +4 more
doaj   +1 more source

Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

Frontiers in Cellular Neuroscience, 2020
Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune ...
Haziq Kamal, G. Tan, S. F. Ibrahim, M. Shaikh, I. Mohamed, R. Mohamed, A. A. Hamid, A. Ugusman, J. Kumar   +8 more
semanticscholar   +1 more source

‐mediated excitotoxicity [PDF]

, 2016
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults including stroke and epilepsy.
Hrdinka, Matous, Jordan, Bryen A., Carbonell, Abigail U., Abigail U Carbonell, Iacobas, Sanda, Lopez-Rojas, Jeffrey, Sanda Iacobas, Karpova, Anna, Dumitru A Iacobas, Michael R Kreutz, Anna Karpova, Kravchick, Dana O., Matous Hrdinka, Bryen A Jordan, Iacobas, Dumitru A., Jeffrey Lopez‐Rojas, Dana O Kravchick, Kreutz, Michael R.   +17 more
core   +1 more source

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

Neuron, 1996
Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of the synthesis of each glutamate transporter subtype using chronic ...
J. Rothstein, M. Dykes‐Hoberg, C. Pardo, L. Bristol, Lin Jin, R. Kuncl, Y. Kanai, M. Hediger, Yanfeng Wang, Jerry P Schielke, D. Welty   +10 more
semanticscholar   +1 more source

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation

Redox Biology, 2020
Background Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies.
Xianrui Song, Zixuan Gong, Kaili Liu, J. Kou, Baolin Liu, Kang Liu   +5 more
semanticscholar   +1 more source

Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

Metabolites, 2023
Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium.
Xue-Jia Qi, Chong-Yin Huang, Meng-Ting Zuo, Meng-Die Gong, Si-Juan Huang, Mo-Huan Tang, Zhao-Ying Liu   +6 more
doaj   +1 more source

Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis.
Amir R. Afshari, Sahar Fanoudi, Arezoo Rajabian, Hamid Reza Sadeghnia, Hamid Mollazadeh, Azar Hosseini   +5 more
doaj   +1 more source