Results 31 to 40 of about 382,255 (259)

Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia

Cells, 2023
A large body of work during the past several decades has been focused on therapeutic strategies to control L-DOPA-induced dyskinesias (LIDs), common motor complications of long-term L-DOPA therapy in Parkinson’s disease (PD).
Brik A. Kochoian, Cassandra Bure, Stella M. Papa   +2 more
doaj   +1 more source

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jun, Xu, Hong, Peng, Ning, Kang, Zhuo, Zhao, Jane H-C, Lin, Patric K, Stanton, Jian, Kang   +6 more
openaire   +2 more sources

Voltage‐gated proton channels in polyneopteran insects

FEBS Open Bio, 2022
Voltage‐gated proton channels (HV1) are expressed in eukaryotes, including basal hexapods and polyneopteran insects. However, currently, there is little known about HV1 channels in insects.
Gustavo Chaves, Christian Derst, Christophe Jardin, Arne Franzen, Boris Musset   +4 more
doaj   +1 more source

Screening of High Yielding Antioxidant Peptide Bacillus sphaericus and Its Application in Value-added Utilization of Soybean Residue

Shipin gongye ke-ji
Objective: Soybean residue, a major by-product of soybean processing, possess nutritional value but have low industrial utilization due to low digestibility and poor palatability.
Qu LIU, Feiyu AN, Rina WU, Ye TIAN, Zhen TIAN, Guoyang PAN, Jinhui JIANG, Xinyu TAO, Yuanyuan MA, Junrui WU   +9 more
doaj   +1 more source

Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study

Endocrine Connections, 2022
Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with gl utamate on diabetic retinopathy (DR) remain unclear.
Chengnan Guo, Yixi Xu, Yange Ma, Xin Xu, Fang Peng, Hui-hui Li, Dongzhen Jin, Shu-zhen Zhao, Zhezheng Xia, Mengyuan Lai, Mingzhu Che, Ruogu Huang, Yanan Wang, Depeng Jiang, Chao Zheng, Guangyun Mao   +15 more
doaj   +1 more source

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

Cells, 2019
The mitochondrial genetic disorder, Leber’s hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4.
Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Tai-Chi Lin, Aliaksandr A. Yarmishyn, Wun-Syuan Chen, De-Kuang Hwang, Guang-Yuh Chiou, Tzu-Wei Lin, Chian-Shiu Chien, Ching-Yao Tsai, Shih-Hwa Chiou, Shih-Jen Chen, Chi-Hsien Peng, Chih-Chien Hsu   +13 more
doaj   +1 more source

p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons

Frontiers in Neuroscience, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo   +16 more
doaj   +1 more source

Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors

eLife, 2014
The circuit structure and function underlying post-coital male behaviors remain poorly understood. Using mutant analysis, laser ablation, optogenetics, and Ca2+ imaging, we observed that following C.
Brigitte LeBoeuf, Paola Correa, Changhoon Jee, L René García   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty

eLife, 2017
We make choices based on the values of expected outcomes, informed by previous experience in similar settings. When the outcomes of our decisions consistently violate expectations, new learning is needed to maximize rewards.
Alexandra Stolyarova, Alicia Izquierdo
doaj   +1 more source