Results 31 to 40 of about 511,305 (158)

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection [PDF]

, 2008
Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell.
Rosso, L., Kaessmann, H., Marques, A.C., Reichert, A.S., Ana C. Marques, Lia Rosso, Reichert, Andreas, Kaessmann, Henrik, Henrik Kaessmann, Marques, Ana C., Andreas S. Reichert, Rosso, Lia, Ana C Marques, Andreas S Reichert, Marques AC, Rosso L, Reichert AS, Kaessmann H   +17 more
core   +2 more sources

Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study

Endocrine Connections, 2022
Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with gl utamate on diabetic retinopathy (DR) remain unclear.
Chengnan Guo, Yixi Xu, Yange Ma, Xin Xu, Fang Peng, Hui-hui Li, Dongzhen Jin, Shu-zhen Zhao, Zhezheng Xia, Mengyuan Lai, Mingzhu Che, Ruogu Huang, Yanan Wang, Depeng Jiang, Chao Zheng, Guangyun Mao   +15 more
doaj   +1 more source

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

Cells, 2019
The mitochondrial genetic disorder, Leber’s hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4.
Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Tai-Chi Lin, Aliaksandr A. Yarmishyn, Wun-Syuan Chen, De-Kuang Hwang, Guang-Yuh Chiou, Tzu-Wei Lin, Chian-Shiu Chien, Ching-Yao Tsai, Shih-Hwa Chiou, Shih-Jen Chen, Chi-Hsien Peng, Chih-Chien Hsu   +13 more
doaj   +1 more source

p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons

Frontiers in Neuroscience, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo   +16 more
doaj   +1 more source

Glutamate-Glutamine cycle parameters.

, 2019
Glutamate-Glutamine cycle parameters.
Yoichiro Mori (8067518), Jorge Riera Diaz (8067515), Austin Tuttle (8067512)   +2 more
core   +1 more source

Screening of High Yielding Antioxidant Peptide Bacillus sphaericus and Its Application in Value-added Utilization of Soybean Residue

Shipin gongye ke-ji
Objective: Soybean residue, a major by-product of soybean processing, possess nutritional value but have low industrial utilization due to low digestibility and poor palatability.
Qu LIU, Feiyu AN, Rina WU, Ye TIAN, Zhen TIAN, Guoyang PAN, Jinhui JIANG, Xinyu TAO, Yuanyuan MA, Junrui WU   +9 more
doaj   +1 more source

Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors

eLife, 2014
The circuit structure and function underlying post-coital male behaviors remain poorly understood. Using mutant analysis, laser ablation, optogenetics, and Ca2+ imaging, we observed that following C.
Brigitte LeBoeuf, Paola Correa, Changhoon Jee, L René García   +3 more
doaj   +1 more source

Regulation of the Maturation of Osteoblasts and Osteoclastogenesis by Glutamate

, 2009
A B S T R A C T Glutamate, an important central excitatory neurotransmitter, is also secreted by osteoblasts and may be involved in the regulation of bone metabolism.
LIN, TZU-HUNG;YANG, RONG-SEN;TANG, CHIH -HSIN;WU, MING-YUEH;FU, WEN-MEI, 林子閎;楊榮森;湯智昕;吳明岳;符文美   +1 more
core   +1 more source

Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty

eLife, 2017
We make choices based on the values of expected outcomes, informed by previous experience in similar settings. When the outcomes of our decisions consistently violate expectations, new learning is needed to maximize rewards.
Alexandra Stolyarova, Alicia Izquierdo
doaj   +1 more source

DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments

STEMedicine, 2022
Synaptic impairment results in cognitive dysfunction of Alzheimer’s disease (AD). As a plant extract, it is found that DL-3-n-butylphthalide (L-NBP) rescues abnormal cognitive behaviors in AD animals.
Qian Ding, Qian Yu, Lei Tao, Yifei Guo, Juan Zhao, Jun Yu   +5 more
doaj   +1 more source