Results 31 to 40 of about 662,038 (354)

Glutamate-Glutamine cycle parameters. [PDF]

, 2019
Glutamate-Glutamine cycle parameters.
Yoichiro Mori (8067518), Jorge Riera Diaz (8067515), Austin Tuttle (8067512)   +2 more
core   +1 more source

Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases

Scientifica, 2013
In the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors.
Makoto Ishikawa
doaj   +1 more source

Glutamate-pantothenate pathway promotes antibiotic resistance of Edwardsiella tarda

Frontiers in Microbiology, 2023
Although cellular metabolic states have been shown to modulate bacterial susceptibility to antibiotics, the interaction between glutamate (Glu) and chloramphenicol (CAP) resistance remains unclear because of the specificity of antibiotics and bacteria ...
Bei-bei Yan, Bei-bei Yan, Xue-sa Dong, Jun-peng Wang, Xiao-ying Li, Xiao-ying Li, Li An, Xi-rong Wang, Long-gang Zhang, Qing-lei Meng, Chao Wang   +10 more
doaj   +1 more source

Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments

Neuron, 2019
The mechanisms underlying the pathophysiology and treatment of depression and stress-related disorders remain unclear, but studies in depressed patients and rodent models are beginning to yield promising insights.
R. Duman, G. Sanacora, J. Krystal
semanticscholar   +1 more source

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells.

Journal of Pharmacological Sciences, 2020
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate transmission efficiency depends on the correct functionality and expression of a plethora of receptors and transporters, located both on neurons and glial cells ...
L. Iovino, M. Tremblay, L. Civiero
semanticscholar   +1 more source

Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]

, 2009
NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S., Hamilton, Nicola; id_orcid, Hamilton, N., Butt, Arthur, Hubbard, Paul, Butt, Arthur M., Hamilton, N, Hubbard, P., Butt, AM   +8 more
core   +1 more source

A Mini-Review of the Role of Glutamate Transporter in Drug Addiction

Frontiers in Neurology, 2019
Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang, Fancai Zeng, Yingying Hu, Xiang Li   +3 more
doaj   +1 more source

Non-canonical glutamate-cysteine ligase activity protects against ferroptosis

bioRxiv, 2020
Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation ...
Y. Kang, Andrea Mockabee-Macias, Chang-An Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett M. Stone, I. Harris, G. DeNicola   +7 more
semanticscholar   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Sylke Müller, Aparicio, I., Eva-Maria Patzewitz, Perner Jan, Isabela Aparicio, Patzewitz, E.-M., Llinas, M., Storm, J., Llinas Manuel, Engel Paul C, Olszewski Kellen, Janet Storm, Perner, J., Storm Janet, Paul C Engel, Kellen Olszewski, Engel, P.C., Manuel Llinas, Olszewski, K., Muller, S., Müller Sylke, Aparicio Isabela, Patzewitz Eva-Maria, Jan Perner   +23 more
core   +1 more source

Cre-Activation in ErbB4-Positive Neurons of Floxed Grin1/NMDA Receptor Mice Is Not Associated With Major Behavioral Impairment

Frontiers in Psychiatry, 2021
Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence.
Anne S. Mallien, Natascha Pfeiffer, Miriam A. Vogt, Sabine Chourbaji, Rolf Sprengel, Rolf Sprengel, Peter Gass, Dragos Inta, Dragos Inta   +8 more
doaj   +1 more source