Results 21 to 30 of about 690,196 (302)

Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels

Cell Reports, 2021
Summary: Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear ...
Cyril Cheret, Marcelo Ganzella, Julia Preobraschenski, Reinhard Jahn, Gudrun Ahnert-Hilger   +4 more
doaj   +1 more source

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

Cells, 2019
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa Mahmoud, Marjan Gharagozloo, Camille Simard, Denis Gris   +3 more
doaj   +1 more source

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]

, 2017
Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y, Bloodgood, Brenda L, Buren, Caodu, Cordes, Thekla, Divakaruni, Ajit S, Fields, Jerel A, Li, Edward, Martyniuk, Kelly, Metallo, Christian M, Murphy, Anne N, Raymond, Lynn A, Reynolds, Ian J, Wallace, Martina   +12 more
core   +1 more source

Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases

Scientifica, 2013
In the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors.
Makoto Ishikawa
doaj   +1 more source

Surface Grafting of Poly(L-glutamates). 2. Helix Orientation [PDF]

, 2001
In this paper the average helix orientation of surface-grafted poly(γ-benzyl L-glutamate) (PBLG), poly(γ-methyl L-glutamate) (PMLG), and poly(γ-methyl L-glutamate)-co-(γ-n-stearyl L-glutamate) (PMLGSLG 70/30) was investigated by means of FT-IR ...
Arndt T., Boncheva M., Chang Y. C., Chang Y. C., Dorman L. C., Duda G., Duda G., Enriquez E. P., Enriquez E. P., Greenler R. G., Jaworek T., Kasuya S., Krimm S., Krimm S., Machida S., Michl J., Miyazawa T., Niwa M., Oosterling M. L. C. M., Poché D. S., Sagiv J., Schmidt M., Torii H., Tsuboi M., Wasserman D., Whitesell J. K., Whitesell J. K., Whitesell J. K., Wieringa R. H., Winter C. S.   +29 more
core   +3 more sources

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jun, Xu, Hong, Peng, Ning, Kang, Zhuo, Zhao, Jane H-C, Lin, Patric K, Stanton, Jian, Kang   +6 more
openaire   +2 more sources

The role of glutamate receptors in the regulation of the tumor microenvironment

Frontiers in Immunology, 2023
Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda, Jing Hu, Jing Hu, Xiaoman Ju, Guowei Sun, Simin Shao, Ren-Xian Tang, Kui-Yang Zheng, Juming Yan   +8 more
doaj   +1 more source

Differential Effects of Dietary MSG on Hippocampal Dependent Memory Are Mediated by Diet

Frontiers in Neuroscience, 2019
IntroductionFree glutamate is a common dietary flavor enhancer and is also an important excitatory neurotransmitter in the body. A good number of food additives which contain glutamate are found in the Western Diet, and this diet has also been linked to ...
Kathleen F. Holton, Sara L. Hargrave, Terry L. Davidson   +2 more
doaj   +1 more source

Glutamate transporter control of ambient glutamate levels

Neurochemistry International, 2014
Accurate knowledge of the ambient extracellular glutamate concentration in brain is required for understanding its potential impacts on tonic and phasic receptor signaling. Estimates of ambient glutamate based on microdialysis measurements are generally in the range of ∼2-10μM, approximately 100-fold higher than estimates based on electrophysiological ...
Sun, Weinan, Shchepakin, Denis, Kalachev, Leonid V., Kavanaugh, Michael P.   +3 more
openaire   +2 more sources