In vivo co-ordinated interactions between inhibitory systems to control glutamate mediated hippocampal excitability. [PDF]
, 2013 We present an overview of the long-term adaptation of hippocampal neurotransmission to cholinergic and GABAergic deafferentation caused by excitotoxic lesion of the medial septum.
Rodríguez Allué, Manuel José +3 more
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Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases
Scientifica, 2013 In the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors.
Makoto Ishikawa
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The role of glutamate receptors in the regulation of the tumor microenvironment
Frontiers in Immunology, 2023 Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda +8 more
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The glutamate post-synaptic density in schizophrenia [PDF]
, 2012 Non-competitive antagonists of the glutamate N-methyl-D-aspartate receptor (NMDAR) induce a broad range of schizophrenia-like symptoms in humans.
Matas, Emmanuel
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Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan +3 more
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Differential Effects of Dietary MSG on Hippocampal Dependent Memory Are Mediated by Diet
Frontiers in Neuroscience, 2019 IntroductionFree glutamate is a common dietary flavor enhancer and is also an important excitatory neurotransmitter in the body. A good number of food additives which contain glutamate are found in the Western Diet, and this diet has also been linked to ...
Kathleen F. Holton +2 more
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Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia
Frontiers in Psychiatry, 2017 BackgroundThe proton magnetic resonance spectroscopy (1H-MRS) signals from glutamate (or the combined glutamate and glutamine signal—Glx) have been found to be greater in various brain regions in people with schizophrenia.
Juan R. Bustillo +26 more
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Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia
Cells, 2023 A large body of work during the past several decades has been focused on therapeutic strategies to control L-DOPA-induced dyskinesias (LIDs), common motor complications of long-term L-DOPA therapy in Parkinson’s disease (PD).
Brik A. Kochoian +2 more
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Voltage‐gated proton channels in polyneopteran insects
FEBS Open Bio, 2022 Voltage‐gated proton channels (HV1) are expressed in eukaryotes, including basal hexapods and polyneopteran insects. However, currently, there is little known about HV1 channels in insects.
Gustavo Chaves +4 more
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New role of glutamate as an immunoregulator via glutamate receptors and transporters [PDF]
, 2011 New role of glutamate as an immunoregulator via glutamate receptors and ...
Field, Catherine J., Xue, Hongyu
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