Results 1 to 10 of about 1,744,648 (406)

3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

Advanced Science, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs.
Yongcong Fang, Chengjin Wang, Ting Zhang
exaly   +2 more sources

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats

Journal of Cellular and Molecular Medicine, 2019
Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration.
Yongbin, Liyang Dong, Dan Zhou
exaly   +2 more sources

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Nature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, G. Kong, Luming Zhou, Greg Crawford, M. Danzi, A. Myridakis, A. Brandis, Adesola T. Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, M. Dumas, J. Strid, S. Mani, Dylan Dodd, S. Di Giovanni   +18 more
semanticscholar   +1 more source

Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Peripheral sensory neurons situated in dorsal root ganglia (DRG) switch to a regenerative state after nerve injury to enable nerve repair. Axon regeneration is not cell autonomous and is highly influenced by nonneuronal cells.
Rui Feng, Vishnu Muraleedharan Saraswathy, Mayssa H. Mokalled, V. Cavalli   +3 more
semanticscholar   +1 more source

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

Advancement of science, 2023
The development of self‐healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits.
Hongyun Xuan, Shuyuan Wu, Yan Jin, Shuo Wei, Feng Xiong, Ye Xue, Biyun Li, Yumin Yang, Huihua Yuan   +8 more
semanticscholar   +1 more source

Enhanced peripheral nerve regeneration by mechano-electrical stimulation

bioRxiv, 2023
To address limitations in current approaches for treating large peripheral nerve defects, the presented study evaluated the feasibility of functional material-mediated physical stimuli on peripheral nerve regeneration.
Youyi Tai, Thamidul Islam Tonmoy, S. Win, Natasha T Brinkley, B. H. Park, Jin Nam   +5 more
semanticscholar   +1 more source

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

Cells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

Advancement of science, 2022
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting.
Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, P. Ho, D. H. Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Qingtang Zhu, L. Bian, Ling Qin   +14 more
semanticscholar   +1 more source

The Effect of Electrical Stimulation on Nerve Regeneration Following Peripheral Nerve Injury

Biomolecules, 2022
Peripheral nerve injuries (PNI) are common and often result in lifelong disability. The peripheral nervous system has an inherent ability to regenerate following injury, yet complete functional recovery is rare.
Luke Juckett, T. Saffari, Benjamin Ormseth, J. Senger, A. Moore   +4 more
semanticscholar   +1 more source

The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration

International Journal on Biological Sciences, 2022
Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface. Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes pathogenesis of diabetes and its complications.
L. Wan, Xiaofei Bai, Qingjun Zhou, Chen Chen, Huifeng Wang, Ting Liu, Jun-li Xue, Chao Wei, Lixin Xie   +8 more
semanticscholar   +1 more source