Results 1 to 10 of about 210,849 (318)

Pseudorabies Virus Mutants Lacking US9 Are Defective in Cytoplasmic Assembly and Sorting of Virus Particles into Axons and Not in Axonal Transport

open access: yesViruses, 2023
Herpes simplex virus (HSV) and varicella zoster virus (VZV) rely on transport of virus particles in neuronal axons to spread from sites of viral latency in sensory ganglia to peripheral tissues then on to other hosts.
Steven Adamou   +2 more
doaj   +1 more source

Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity

open access: yesCell Reports, 2021
Summary: The 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular localization and translation.
Catia Andreassi   +10 more
doaj   +1 more source

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

open access: yeseLife, 2021
During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive ...
Patrick C Hoffmann   +6 more
doaj   +1 more source

The Flow of Axonal Information Among Hippocampal Subregions: 1. Feed-Forward and Feedback Network Spatial Dynamics Underpinning Emergent Information Processing

open access: yesFrontiers in Neural Circuits, 2021
The tri-synaptic pathway in the mammalian hippocampus enables cognitive learning and memory. Despite decades of reports on anatomy and physiology, the functional architecture of the hippocampal network remains poorly understood in terms of the dynamics ...
Yash S. Vakilna   +4 more
doaj   +1 more source

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

open access: yesToxics, 2020
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental disorders defined clinically by core deficits in social reciprocity and communication, restrictive interests and repetitive behaviors.
Harmanpreet Kaur Panesar   +3 more
doaj   +1 more source

Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3′-Dichlorobiphenyl (PCB 11)

open access: yesToxics, 2017
PCB 11 is an emerging global pollutant that we recently showed promotes axonal and dendritic growth in primary rat neuronal cell cultures. Here, we address the influence of sex and species on neuronal responses to PCB 11.
Sunjay Sethi   +2 more
doaj   +1 more source

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

open access: yesFrontiers in Cellular Neuroscience, 2019
Understanding the role of axons in neuronal information processing is a fundamental task in neuroscience. Over the last years, sophisticated patch-clamp investigations have provided unexpected and exciting data on axonal phenomena and functioning, but ...
Torsten Bullmann   +10 more
doaj   +1 more source

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders

open access: yesProteomes, 2018
The mammalian nervous system is an immensely heterogeneous organ composed of a diverse collection of neuronal types that interconnect in complex patterns.
Yi-Zhi Wang, Jeffrey N. Savas
doaj   +1 more source

Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

open access: yesFrontiers in Computational Neuroscience, 2023
The self-organization of the brain matrix of serotonergic axons (fibers) remains an unsolved problem in neuroscience. The regional densities of this matrix have major implications for neuroplasticity, tissue regeneration, and the understanding of mental ...
Skirmantas Janušonis   +4 more
doaj   +1 more source

Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation

open access: yesCells, 2023
Rapid responses to changes within subcellular compartments of highly polarized cells, such as neuron axons, depend on local translation and post-transcriptional regulation.
Luba Farberov   +7 more
doaj   +1 more source

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