Results 21 to 30 of about 6,219 (219)
Frontiers in Neurology, 2020 Traumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target.
Ciaran S. Hill +8 more
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The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish
Frontiers in Molecular Neuroscience, 2020 Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless,
Jie Gong +12 more
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Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity
Cell Reports, 2021 Summary: The 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular localization and translation.
Catia Andreassi +10 more
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Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra +6 more
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eLife, 2021 During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive ...
Patrick C Hoffmann +6 more
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Neuron Names: A Gene- and Property-Based Name Format, With Special Reference to Cortical Neurons
Frontiers in Neuroanatomy, 2019 Precision in neuron names is increasingly needed. We are entering a new era in which classical anatomical criteria are only the beginning toward defining the identity of a neuron as carried in its name.
Gordon M. Shepherd +14 more
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Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
eLife, 2019 Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan +7 more
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Frontiers in Neural Circuits, 2021 The tri-synaptic pathway in the mammalian hippocampus enables cognitive learning and memory. Despite decades of reports on anatomy and physiology, the functional architecture of the hippocampal network remains poorly understood in terms of the dynamics ...
Yash S. Vakilna +4 more
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eLife, 2016 The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Tau in
Andre Voelzmann +6 more
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Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination
Frontiers in Neuroanatomy, 2021 Mitochondria are essential for neurons and must be optimally distributed along their axon to fulfill local functions. A high density of mitochondria has been observed in retinal ganglion cell (RGC) axons of an unmyelinated region of the optic nerve ...
Samantha J. Wilkison +10 more
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