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Neurotrophic factors in multiple sclerosis [PDF]
Frontiers in ImmunologySmoldering inflammation and neurodegeneration, primarily driven by intraparenchymal immune cell activation and glial dysfunction, remains a major therapeutic challenge in Multiple Sclerosis (MS) and contributes largely to disability progression.
Fabian Güner +3 more
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Depression, Neuroplasticity and Neurotrophic Factors [PDF]
Psikiyatride Güncel Yaklaşımlar, 2009 Depression is a common psychiatric disorder. There is still very little known about the neurobiological alterations that underlie the pathophysiology of depression.
Cengiz Akkaya +3 more
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Neural Regeneration Research, 2022 [INLINE:1] The introduction of neurotrophic factors into injured peripheral nerve sites is beneficial to peripheral nerve regeneration. However, neurotrophic factors are rapidly degraded in vivo and obstruct axonal regeneration when used at a ...
Ci Li +7 more
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Neurotrophic signaling in liver cancers: mechanisms and potential therapeutic targets [PDF]
Exploration of Digestive DiseasesRecent studies demonstrate that peripheral innervation and Schwann cells (SCs) activity within the tumor microenvironment (TME) have a significant influence on liver cancer, specifically hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (
Lorenzo Mainardi +2 more
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Neurotrophic Factors in Multiple Sclerosis: a Review of the Mechanism [PDF]
Neurology LettersThe objective of this review is to examine the mechanistic roles of neurotrophic factors (NTFs) in the pathology of multiple sclerosis (MS) and their potential as therapeutic agents. MS is a chronic autoimmune disease of the central nervous system (CNS),
Samaneh Azizpour, Vahid Moghadasi
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Cell Transplantation, 1996 Neuronal and axonal responses to neurotrophic factors in the developing spinal cord have been relatively well characterized, but little is known about adult spinal responses to neurotrophic factors.
Yasushi Nakahara +2 more
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Scientific Reports, 2021 Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime ...
Dreu White +11 more
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ELISA‐based quantification of neurotrophic growth factors in urine from prostate cancer patients
FASEB BioAdvances, 2021 Non‐invasive procedures are needed for prostate cancer management, and urine represents a potential source of new biomarkers with translational value. Recent evidence has shown that the growth of new nerves in the tumor microenvironment is essential to ...
Brayden March +5 more
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Neurotrophic factors and corneal nerve regeneration
Neural Regeneration Research, 2017 The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination.
Marta Sacchetti, Alessandro Lambiase
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Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. [PDF]
PLoS ONE, 2015 PURPOSE:The skeletal muscle develops various degrees of atrophy and metabolic dysfunction following nerve injury. Neurotrophic factors are essential for muscle regeneration.
Chun-Jung Chen +8 more
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