Results 21 to 30 of about 7,532,121 (298)

Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum

Neurobiology of Disease, 2005
We have carried out cDNA array analysis in order to characterize the gene expression profiles of reactive astrocytes from dopamine-depleted striatum.
Takao Nakagawa, Takeshi Yabe, Joan P. Schwartz   +2 more
doaj   +1 more source

Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells. [PDF]

PLoS ONE, 2011
Recent studies have indicated that the choice of lineage of neural progenitor cells is determined, at least in part, by environmental factors, such as neurotrophic factors.
Masaya Nakamura, Osahiko Tsuji, Barbara S Bregman, Yoshiaki Toyama, Hideyuki Okano   +4 more
doaj   +1 more source

MANF: A New Player in the Control of Energy Homeostasis, and Beyond

Frontiers in Physiology, 2018
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and ...
Su Yang, Shihua Li, Xiao-Jiang Li
doaj   +1 more source

The Role of BDNF on Neural Plasticity in Depression

Frontiers in Cellular Neuroscience, 2020
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala ...
Tao Yang, Zheng Nie, Haifeng Shu, Yongqin Kuang, Xin Chen, Jingmin Cheng, Sixun Yu, Huiying Liu   +7 more
doaj   +1 more source

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Zhuang, X. X., Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, M. P., Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Ramakers, G. M. J., Kramer, E. R., Kramer Edgar R, Ramakers, Geert M. J, Smidt Marten P, Ramakers Geert M. J, Seitz Sabine, Aron Liviu, Zhuang Xiaoxi, Beyer Klaus, Klein Rüdiger   +36 more
core   +2 more sources

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

Neural Regeneration Research, 2017
Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has
Tuane Bazanella Sampaio, Anne Suely Savall, Maria Eduarda Ziani Gutierrez, Simone Pinton   +3 more
doaj   +1 more source

Collagen scaffold loaded allogeneic neural stem cells promoted locomotion recovery of spinal cord injury mainly through secreting neurotrophic factors

Materials & Design, 2022
The combination of biological scaffold and neural stem cells (NSCs) is a promising treatment strategy for spinal cord injury (SCI). But adverse niche at injures spinal cord severe hamper the transplanted NSCs to preferentially differentiate neurons.
Shuo Liu, Caixia Fan, Yuanyuan Xie, Liudi Wang, Yanyan Cui, Bin Wang   +5 more
doaj   +1 more source

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

Life, 2023
The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested.
Tadahiro Numakawa, Ryutaro Kajihara
doaj   +1 more source

A Neurotrophic Model of the Development of the Retinogeniculocortical Pathway Induced by Spontaneous Retinal Waves

, 1999
The development of the retinogeniculate pathway or the geniculocortical pathway, or both, occurs either before birth or before eye opening in many species.
Shadbolt, N. R, Terry Elliott, Elliott, T, Nigel R. Shadbolt   +3 more
core   +2 more sources

Neurotrophic factor-based pharmacological approaches in neurological disorders

Neural Regeneration Research, 2023
Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer’s disease, Parkinson’s ...
Margherita Alfonsetti, Michele d’Angelo, Vanessa Castelli   +2 more
doaj   +1 more source