Nerve Growth Factor and Pain Mechanisms
Annual Review of Neuroscience, 2017 Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology.
David Bennett +2 more
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Gelatin Methacrylic Acid Hydrogel-Based Nerve Growth Factors Enhances Neural Stem Cell Growth and Differentiation to Promote Repair of Spinal Cord Injury. [PDF]
Int J NanomedicineMingkui Shen,1,* Lulu Wang,2,* Kuankuan Li,1 Jun Tan,1,3 Zhongxin Tang,1 Xiaohu Wang,4 Hejun Yang1 1Department of Mini-Invasive Spinal Surgery, The Third People’s Hospital of Henan Province, Zhengzhou, Henan, 450006, People’s Republic of China ...
Shen M +6 more
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Nihon Naika Gakkai Zasshi, 1992 神経成長因子(nerve growth factor; NGF)は,知覚神経二ューロン,交感神経ニューロン,中枢の一部のコリン系ニューロンの分化・成熟を促し,生存・機能を維持し,突起伸展を引き起こす,分子量約26000の蛋白質である. NGFは,神経科学,発生学の分野において最も古くから実体の明らかにされていた分子のひとつで, NGFの研究で得られた膨大な知見から神経回路の形成過程や調節機構の概要が窺い知ることができるようになった.最近では, NGFを投与すると,末梢神経の軸索再生が促進されること,遅発性ニューロン死が抑制されること,老化による学習記憶能力低下が抑制されること,などが報告され,臨床応用への期待も高まってきている.
Y, Furukawa, S, Furukawa
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Nerve Growth Factor and Autoimmune Diseases
Current Issues in Molecular Biology, 2023 NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues.
Sergio Terracina +10 more
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Nerve growth factor binding domain of the nerve growth factor receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A structural analysis of the rat low-affinity nerve growth factor (NGF) receptor was undertaken to define the NGF binding domain. Mutant NGF receptor DNA constructs were expressed in mouse fibroblasts or COS cells, and the ability of the mutant receptor to bind NGF was assayed.
A A, Welcher +3 more
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Journal of Investigative Dermatology, 1994 Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R).
PINCELLI, Carlo +9 more
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NERVE GROWTH FACTOR AND AUTOIMMUNE DISEASES
Autoimmunity, 1994 The initiation of a humoral immune response to a foreign antigen is a complex biologic process involving the interaction of many cell types and their secreted products. Autoimmune diseases, which are characterized by an abnormal activation of the immune system, probably result from the failure of normal self-tolerance mechanisms.
L, Aloe +3 more
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ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors. [PDF]
World J Stem Cells, 2023 Zheng ZK +4 more
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Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial. [PDF]
Nutrients, 2019 Sumiyoshi E +8 more
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Correction to "ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors". [PDF]
World J Stem CellsDai M.
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