Results 11 to 20 of about 12,228,580 (237)

An organized 3D in vitro model for peripheral nerve studies [PDF]

, 2013
Three-dimensional cell cultures have been proposed to address the limitations in two-dimensional cell cultures (i.e. lack of relevant architectural features) and very few have developed 3D cell culture methods for peripheral nerve studies. Therefore, the
Daud, Muhammad Fauzi
core   +6 more sources

Analysis of the C/EBP family of transcription factors in neuronal repair [PDF]

, 2009
PhDNeurons within the peripheral nervous system (PNS) have a remarkable ability to repair themselves after injury; however, neurons within the central nervous system (CNS) do not spontaneously regenerate.
López de Heredia, Luis
core   +4 more sources

Expression of neuropeptides – galanin and Reg2 - in subcategories of nociceptors after nerve injury [PDF]

, 2010
PhDNeuropeptides show dynamic changes in expression after nerve injury, and have been implicated in chronic pain states. I sought to compare expression of two peptides which are upregulated after nerve injury, galanin and Reg2, and to determine the ...
Burrows, Karen Lynne
core   +4 more sources

Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury [PDF]

, 2012
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
Vivien Szabo, Scamps, Frédérique, Végh Attila-Gergely, Attila-Gergely Végh, Lucas Olivier, Scamps Frédérique, Ouafa Benzina, Thierry Cloitre, Csilla Gergely, Benzina Ouafa, Szabo, Vivian, Szabo, Vivien, Cloitre, Thierry, Marta Martin, Gergely, Csilla, Frédérique Scamps, Szabo Vivien, Cloitre Thierry, Olivier Lucas, Gergely Csilla, Benzina, Ouafa, Lucas, Olivier, Martin Marta, Martin, Marta, Végh, Attila Gergely   +24 more
core   +2 more sources

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A.   +45 more
core   +2 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Spatial pattern of nerve differentiation in Hydra is due to a pattern of nerve commitment [PDF]

, 1981
The pattern of nerve differentiation along the body column of Hydra was investigated. Nerve precursors in late S phase were labeled with [3H]thymidine and their distribution compared with that of newly differentiated nerves.
G. Venugopal, Venugopal, G., Charles N. David, David, Charles N.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source