Results 31 to 40 of about 480,406 (311)

Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury

Neural Regeneration Research, 2022
The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability.
Kamilla Faritovna Idrisova, Alina Kazymovna Zeinalova, Galina Andreevna Masgutova, Alexey Andreevich Bogov, Cinzia Allegrucci, Valeriia Yurievna Syromiatnikova, Ilnur Ildusovich Salafutdinov, Ekaterna Evgenievna Garanina, Dina Ivanovna Andreeva, Adilet Abdullaatovich Kadyrov, Albert Anatolevich Rizvanov, Ruslan Faridovich Masgutov   +11 more
doaj   +1 more source

Neurotrophic Factor Changes in the Rat Thick Skin following Chronic Constriction Injury of the Sciatic Nerve [PDF]

, 2012
Background: Cutaneous peripheral neuropathies have been associated with changes of the sensory fiber innervation in the dermis and epidermis. These changes are mediated in part by the increase in local expression of trophic factors.
Jennifer C Peleshok, Alfredo Ribeiro-da-Silva   +1 more
core   +1 more source

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats

Brazilian Journal of Otorhinolaryngology, 2023
Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.
Aracele Gonçalves Vieira, Fausto Pierdona Guzen, José Rodolfo Lopes de Paiva, Lucídio Clebeson de Oliveira, Maria Clara de Araújo Jales, Eudes Euler de Souza Lucena, Virgínia Raquel dos Santos Lucena, Hécio Henrique Araújo de Morais   +7 more
doaj   +1 more source

Synergistic Enhancement of Peripheral Nerve Regeneration via Ibudilast-Primed Three-Dimensional Spheroid Culture of Human Adipose-Derived Stem Cells

Pharmaceuticals
Background: Peripheral nerve regeneration relies on Schwann cell activation and neurotrophic support. Although adipose-derived stem cells (ADSCs) show therapeutic potential through paracrine mechanisms, their clinical application is often limited by ...
Ji Young Bang, Nam-Kyu Lim
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. [PDF]

, 2017
The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI).
Charsar, Brittany A., Lepore, Angelo C., Urban, Mark W.   +2 more
core   +2 more sources

Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate ceftriaxone’s potential in enhancing peripheral nerve injuries (PNIs) recovery. Methods: Thirty male Wistar rats were divided into control (no surgery), vehicle (sciatic nerve injury + 0.9% NaCl), and ceftriaxone (sciatic nerve ...
Berkin Gunar, Ejder Saylav Bora, Osman Mert Topkar, Özgür Baysal, Ziya Shammadli, Oytun Erbas   +5 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Can ReGeneraTing Agents Improve Functional Recovery of Transected Peripheral Nerve through a Nerve Gap Bridged with an Artery Graft?

Journal of Reconstructive Microsurgery Open, 2019
Background The purpose of this study was to use artery grafts filled with CACIPLIQ20 and see if they promote nerve regeneration. Methods Sixty male Wistar rats were used. The rats were randomly divided into four experimental groups (n = 15):
George Alexopoulos, Leonidas Pavlidis, Myron Tsagarakis, Alexandros Delimpaltas, Antonios Tsimponis, Apostolos Papalois, Anna Batistatou, Alexandra Papoudou-Bai, Denis Barritault, Efterpi Demiri, Georgia Alexandra Spyropoulou   +10 more
doaj   +1 more source

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]

, 2009
A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor, Blesch, Armin, Conner, James M, Havton, Leif A, Hollis, Edmund R, Tuszynski, Mark H   +5 more
core   +2 more sources