Volumetric MRI is a promising outcome measure of muscle reinnervation
Scientific Reports, 2021 The development of outcome measures that can track the recovery of reinnervated muscle would benefit the clinical investigation of new therapies which hope to enhance peripheral nerve repair. The primary objective of this study was to assess the validity
Matthew Wilcox +8 more
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Characterising cellular and molecular features of human peripheral nerve degeneration
Acta Neuropathologica Communications, 2020 Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it is known that the regenerative capacity of the peripheral nervous system (PNS) relies heavily on the remarkable ability of Schwann cells to ...
Matthew B. Wilcox +6 more
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Cortical plasticity and nerve regeneration after peripheral nerve injury
Neural Regeneration Research, 2021 With the development of neuroscience, substantial advances have been achieved in peripheral nerve regeneration over the past decades. However, peripheral nerve injury remains a critical public health problem because of the subsequent impairment or ...
Ci Li +3 more
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Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
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Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. [PDF]
, 2018 BACKGROUND:In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activity after ...
Angert, Mila +6 more
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Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury [PDF]
, 2017 Macro-sieve electrodes were implanted in the sciatic nerve of five adult male Lewis rats following spinal cord injury to assess the ability of the macro-sieve electrode to interface regenerated peripheral nerve fibers post-spinal cord injury. Each spinal
Birenbaum, Nathan K +2 more
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Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
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Assessment, patient selection, and rehabilitation of nerve transfers
Frontiers in Rehabilitation Sciences, 2023 Peripheral nerve injuries are common and can have a devastating effect on physical, psychological, and socioeconomic wellbeing. Peripheral nerve transfers have become the standard of care for many types of peripheral nerve injury due to their superior ...
Emma A. Bateman +8 more
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Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair [PDF]
, 2016 Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood.
Carlin, Dan +8 more
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Extraskeletal Ewing’s Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge
Case Reports in Surgery, 2015 Ewing’s sarcoma is a common bone tumour of childhood but is a rare occurrence in individuals over 20 years of age. Few cases are reported as originating from peripheral nerves.
Aadhar Sharma +4 more
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