Results 21 to 30 of about 286,657 (266)

Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury [PDF]

, 2012
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
A Nilsson, A Vinckier, AB Huber, AB Mathur, AL Weisenhorn, AR Bausch, Attila-Gergely Végh, B Geiger, C Hilaire, ChC Dupont-Gillain, Csilla Gergely, DM Suter, DS Smith, E Evans, E Spedden, EW Dent, F Charron, Frédérique Scamps, H-J Butt, HA McNally, HA McNally, HJ Song, HS Xiao, I Mechaly, Igor Sokolov, IN Sneddon, J Dai, J Laishram, J Sleep, JL Goldberg, K Tanaka, KD Costa, L Lankford K, M Mustata, M Radmacher, M Radmacher, Marta Martin, MG Hertz, MJ Rosenbluth, Olivier Lucas, Ouafa Benzina, OV Chumakova, PN Hoffman, R García, R Lal, S Andre, S Pieraut, S Pieraut, SS Hannila, T Araki, T Tojima, TC Dickson, Thierry Cloitre, TS Lanero, V Heinrich, Vivien Szabo, Y Xiong, ZL Chen   +57 more
core   +5 more sources

The role of exercise on peripheral nerve regeneration: from animal model to clinical application

Heliyon, 2021
Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important ...
Grazia Maugeri, Velia D'Agata, Bruno Trovato, Federico Roggio, Alessandro Castorina, Michele Vecchio, Michelino Di Rosa, Giuseppe Musumeci   +7 more
doaj   +1 more source

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
Jessen, KR, Mirsky, R, Patterson, PH, Tofaris, GK   +3 more
core   +2 more sources

Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (ATR) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies

Molecular Pain, 2015
Background The clinical efficacy of the Angiotensin II (AngII) receptor AT 2 R antagonist EMA401, a novel peripherallyrestricted analgesic, was reported recently in post-herpetic neuralgia.
Uma Anand, Yiangos Yiangou, Marco Sinisi, Michael Fox, Anthony MacQuillan, Tom Quick, Yuri E Korchev, Chas Bountra, Tom McCarthy, Praveen Anand   +9 more
doaj   +1 more source

Development of a core outcome set for traumatic brachial plexus injuries (COMBINE): study protocol

BMJ Open, 2019
IntroductionTraumatic brachial plexus injury (TBPI) involves major trauma to the large nerves of the arm which control the movement and sensation. Fifty per cent of injuries result in complete paralysis of the arm with many other individuals having ...
Christina Jerosch-Herold, Caroline Miller, Jane Cross, Dominic M Power   +3 more
doaj   +1 more source

MicroRNAs modulate schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes [PDF]

, 2011
In the peripheral nervous system, Schwann cells (SCs) surrounding damaged axons undergo an injury response that is driven by an intricate transcriptional program and is critical for nerve regeneration.
Chang, Li-Wei, Fahrner, Timothy, Milbrandt, Jeffrey, Nagarajan, Rakesh, Viader, Andreu   +4 more
core   +2 more sources

Lumbosacral Plexogram: An Aid to Reconstructive Nerve Possibilities in the Lower Extremity

Plastic and Reconstructive Surgery, Global Open
Summary:. The lumbosacral plexus is the network of nerves responsible for the motor and sensory function of the pelvis and lower limb. Our observation is that the anatomy of this plexus is less familiar to surgeons than that of the brachial plexus ...
Sami Ramadan, FRCS(Plast), Catherine Leng, MRCS, Liron S. Duraku, MD, PhD, Tahseen Chaudhry, FRCS(Tr&Orth), Dominic M. Power, FRCS(Tr&Orth), Samuel George, FRCS(Plast)   +5 more
doaj   +1 more source

Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation [PDF]

, 2005
A unilateral facial nerve injury (n7x) was found to influence the transcallosal spread of the attenuated strain of pseudorabies virus (PRV Bartha) from the affected (left) primary motor cortex (MI) to the contralateral MI of rats.
Boda, Krisztina, Boldogkői, Zsolt, Farkas, Tamás, Horváth, Szatmár, Janka, Zoltán, Kis, Zsolt, Pankotai, Eszter, Prandovszky, Emese, Toldi, József   +8 more
core   +1 more source

Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

Scientific Reports, 2023
Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been developed to localize Sigma-1 Receptor and thus image pain source.
Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, Anand Veeravagu   +6 more
doaj   +1 more source

Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury [PDF]

, 2009
Background: After peripheral nerve injury, spontaneous ectopic activity arising from the peripheral axons plays an important role in inducing central sensitization and neuropathic pain.
Marc R Suter, Temugin Berta, Yong-Jing Gao, Isabelle Decosterd, Ru-Rong Ji, Devor M, Wu G, Michaelis M, Horner PJ, Jin SX, Szallasi A, Ali Z, Pan HL, Kajander KC, O'Brien JJ   +14 more
core   +4 more sources