Results 1 to 10 of about 19,186,071 (258)

Beyond the Central Nervous System: Uncovering Memantine’s Modulatory Role in the Peripheral Nervous System [PDF]

Medicines
Background: Memantine, an uncompetitive and voltage-dependent N-methyl-D-aspartate (NMDA) receptor antagonist, is clinically established for moderate-to-severe Alzheimer’s disease. Its pharmacodynamic profile, low-to-moderate affinity, rapid open-channel
Kyriaki Papadopoulou, Sophia Tsokkou, Ioannis Konstantinidis, Pavlos Pavlidis, Chrysanthi Sardeli, Dimitrios Kouvelas, Soultana Meditskou-Efthymiadou, Antonia Sioga, Theodora Papamitsou   +8 more
doaj   +2 more sources

Peripheral nervous system involvement accompanies central nervous system involvement in anti-N-methyl-D-aspartate receptor encephalitis [PDF]

Frontiers in Immunology
BackgroundAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis, primarily affecting the central nervous system (CNS) and typically presenting with neuropsychiatric symptoms.
Wenjie Wang, Lihui Zhu, Zhiting Li, Liran Qin, Hongying Liu, Li Wu, Youming Long, Xuelong Li, Xianliang Li, Jun Liu   +9 more
doaj   +2 more sources

Women in the field of multiple sclerosis: How they contributed to paradigm shifts

Frontiers in Molecular Neuroscience, 2023
History is full of women who made enormous contributions to science. While there is little to no imbalance at the early career stage, a decreasing proportion of women is found as seniority increases.
Andreia Barateiro, Andreia Barateiro, Catarina Barros, Maria V. Pinto, Ana Rita Ribeiro, Ainhoa Alberro, Ainhoa Alberro, Adelaide Fernandes, Adelaide Fernandes   +8 more
doaj   +1 more source

Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2021
Since neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function.
Seiichi Nagano, Seiichi Nagano, Toshiyuki Araki   +2 more
doaj   +1 more source

The complex relationship between obesity and neurodegenerative diseases: an updated review

Frontiers in Cellular Neuroscience, 2023
Obesity is a global epidemic, affecting roughly 30% of the world’s population and predicted to rise. This disease results from genetic, behavioral, societal, and environmental factors, leading to excessive fat accumulation, due to insufficient energy ...
Alexandre Neto, Adelaide Fernandes, Adelaide Fernandes, Andreia Barateiro, Andreia Barateiro   +4 more
doaj   +1 more source

Immunohistochemical demonstration of specific antigens in the human brain fixed in zinc-ethanol-formaldehyde

European Journal of Histochemistry, 2015
Tissue fixation is critical for immunohistochemistry. Recently, we developed a zinc-ethanol-formalin fixative (ZEF), and the present study was aimed to assess the applicability of the ZEF for the human brain histology and immunohistochemistry and to ...
D.E. Korzhevskii, E.G. Sukhorukova, O.V. Kirik, I.P. Grigorev   +3 more
doaj   +1 more source

First Family of MATR3-Related Distal Myopathy From Italy: The Role of Muscle Biopsy in the Diagnosis and Characterization of a Still Poorly Understood Disease

Frontiers in Neurology, 2021
Mutations in the MATR3 gene are associated to distal myopathy with vocal cord and pharyngeal weakness (VCPDM), as well as familiar and sporadic motor neuron disease.
Michele Cavalli, Rosanna Cardani, Laura Valentina Renna, Mauro Toffetti, Luisa Villa, Giovanni Meola   +5 more
doaj   +1 more source

Miller Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain-Barré syndrome overlap with persistent non-demyelinating conduction blocks: a case report

BMC Neurology, 2018
Background Miller Fisher syndrome (MFS) and Bickerstaff’s Brainstem Encephalitis (BBE) share some clinical features and a common immunological profile characterized by anti-GQ1b antibodies.
Angela Puma, Jeanne Benoit, Sabrina Sacconi, Antonino Uncini   +3 more
doaj   +1 more source

Evaluating the frequency of neurological symptoms in COVID‐19 patients: A cross‐sectional study

Health Science Reports, 2023
Background and Aims Due to the recent emergence of COVID‐19, the exact pathology of this disease has not been determined. Therefore, this study evaluated the frequency of neurological symptoms in patients with COVID‐19. Methods This cross‐sectional study
Shima Rasouli, Payam Emami, Farhad Azadmehr, Farzaneh Karimyan   +3 more
doaj   +1 more source

Outcomes of Hybrid Cement-Augmented Pedicle Screw Fixation in Complicated Osteoporotic Thoracolumbar Fractures: A Single-Centre Experience

Medicina
Background and Objectives: Complicated osteoporotic thoracolumbar fractures represent a major surgical challenge because compromised bone quality predisposes to progressive deformity, neurological deterioration, and fixation failure.
Nurzhan Abishev, Talgat Kerimbayev, Daryn Borangaliyev, Galymzhan Kadirbekov, Zhandos Tuigynov, Yermek Urunbayev, Meirzhan Oshayev, Viktor Aleinikov, Yergen Kenzhegulov, Medet Toleubayev, Mariya Dmitriyeva, Makar Solodovnikov, Serik Akshulakov   +12 more
doaj   +1 more source