Results 41 to 50 of about 475,670 (262)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Microglia Involvement into Acute and Chronic Brain Damage in Diabetic Rats: Impact of GLP-1RA and SGLT-2i

Frontiers in Bioscience-Landmark
Background: Acute and chronic brain damage in type 2 diabetes mellitus (DM) determines the need to investigate the neuroprotective potential of glucose-lowering drugs.
Anna Simanenkova, Oksana Fuks, Natalya Timkina, Alina Islamova, Dina Sufieva, Оlga Kirik, Dmitrii Korzhevskii, Timur Vlasov, Tatiana Karonova   +8 more
doaj   +1 more source

PERIPHERAL NERVOUS SYSTEM INVOLVEMENT IN LYMPHOPROLIFERATIVE DISORDERS

Mediterranean Journal of Hematology and Infectious Diseases, 2018
Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable ...
Mario Sabatelli, Luca Laurenti, Marco Luigetti   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Peripheral nervous system in limited systemic sclerosis

Reumatismo, 2011
Objectives. PNS is involved in Systemic Sclerosis (SSc) since the earliest phases. Our aim is to perform an ultrastructural study on skin PNS fibers in SSc. Methods.
D. Melchiorre, S. Guiducci, S. Generini, A. Franca Milia, D. Nosi, A. Tani, L. Ibba Manneschi, A. Del Rosso, A. Pignone, M. Matucci Cerinic   +9 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Characterizing white matter hyperintensities in myotonic dystrophy type 1 through IVIM derived metrics

Scientific Reports
Myotonic dystrophy type 1 (DM1) is a genetic disease which affects multiple systems including the central nervous system. One of its key neuroimaging biomarkers are white matter hyperintensities (WMHs). The clinical relevance of WMHs remains unclear, and
Marina Di Stefano, Nivedita Agarwal, Giulia Canella, Eleonora Diella, Morena delle Fave, Giovanni Meola, Maria Grazia D’Angelo, Denis Peruzzo   +7 more
doaj   +1 more source

Peripheral nervous system involvement in systemic amyloidosis

Неврология, нейропсихиатрия, психосоматика, 2018
Peripheral nervous system involvement may be a main manifestation of systemic amyloidosis or occur in the later stages of the disease in the presence of multiple organ pathology.
E. I. Safiulina, O. E. Zinovyeva, V. V. Rameev, L. V. Kozlovskaya-Lysenko   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Musculoskeletal and Peripheral Nervous System Involvement in a Patient Undergoing Chronic Hemodialysis: A Case Report and Literature Review

Türk Osteoporoz Dergisi, 2021
Musculoskeletal system manifestations in chronic renal insufficiency are caused by complex bone metabolism alterations, which is now described under the umbrella term of chronic kidney disease mineral- and bone-related disorder instead of renal ...
Zeynep Tuba Bahtiyarca, Fatma Aytül Çakcı   +1 more
doaj   +1 more source