Results 51 to 60 of about 18,217,681 (301)

Drugs and the peripheral nervous system [PDF]

, 2017
Contents\ud \ud 7.1. Drugs and the sympathetic nervous system\ud \ud - 7.1.1 The sympathetic nervous system\ud \ud \ud - 7.1.2 Effects of the sympathetic nervous system\ud \ud \ud - 7.1.3 Sympathomimetics\ud \ud \ud - 7.1.4 Selective α1-adrenoceptor ...
Doggrell, Sheila
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation

Neuroscience Research
Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep apnea
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki   +7 more
doaj   +1 more source

MFN2 KNOCKDOWN CAUSES NEUROMUSCULAR ALTERATIONS DURING ZEBRAFISH (DANIO RERIO) DEVELOPMENT: CHARACTERIZATION AND ANALYSIS OF A NEW MODEL FOR CHARCOT-MARIE-TOOTH TYPE 2A NEUROPATHY [PDF]

, 2011
Charcot-Marie-Tooth (CMT) diseases are the most common hereditary diseases of the peripheral nervous system. One of the most frequent, the dominant subtype CMT2A, is caused by mutations in the MFN2 gene coding for mitofusin 2, a dynamin-like GTPase ...
VETTORI, ANDREA, ARGENTON, FRANCESCO, TISO, NATASCIA, MOSTACCIUOLO, MARIA LUISA, VAZZA, GIOVANNI, BERGAMIN, GIORGIA, Polo G, MORO, ENRICO   +7 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats

Journal of Veterinary Internal Medicine, 2022
Background Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking.
Alexane Durand, Erin Keenihan, Daniela Schweizer, Arianna Maiolini, Julien Guevar, Anna Oevermann, Rodrigo Gutierrez‐Quintana   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High Resolution Ultrasound in the Evaluation and Management of Traumatic Peripheral Nerve Injuries: Review of the Literature

Oman Medical Journal, 2014
High-resolution ultrasound has been used as an important tool in the diagnosis, management and monitoring of both acute and chronic peripheral nerve injuries.
Ahmed Alaqeel, Feras Alshomer
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Long term clinical outcomes of minimally invasive transforaminal interbody fusion (MIS-TLIF) for lumbar spondylolisthesis in a geriatric (>65 years) population: a systematic review and meta-analysis

Frontiers in Surgery
IntroductionThe minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) technique has become a popular and effective option for treating lumbar degenerative spondylolisthesis, especially in elderly patients.
Talgat Kerimbayev, Yerzhan Kuanyshbekov, Serik Akshulakov, Indira Karibayeva   +3 more
doaj   +1 more source