Results 61 to 70 of about 19,186,071 (258)

Collagen VI in healthy and diseased nervous system

Disease Models & Mechanisms, 2018
Collagen VI is a major extracellular matrix protein exerting a number of functions in different tissues, spanning from biomechanical to regulatory signals in the cell survival processes, and playing key roles in maintaining the stemness or determining ...
Ilaria Gregorio, Paola Braghetta, Paolo Bonaldo, Matilde Cescon   +3 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Characterizing white matter hyperintensities in myotonic dystrophy type 1 through IVIM derived metrics

Scientific Reports
Myotonic dystrophy type 1 (DM1) is a genetic disease which affects multiple systems including the central nervous system. One of its key neuroimaging biomarkers are white matter hyperintensities (WMHs). The clinical relevance of WMHs remains unclear, and
Marina Di Stefano, Nivedita Agarwal, Giulia Canella, Eleonora Diella, Morena delle Fave, Giovanni Meola, Maria Grazia D’Angelo, Denis Peruzzo   +7 more
doaj   +1 more source

Microglia Involvement into Acute and Chronic Brain Damage in Diabetic Rats: Impact of GLP-1RA and SGLT-2i

Frontiers in Bioscience-Landmark
Background: Acute and chronic brain damage in type 2 diabetes mellitus (DM) determines the need to investigate the neuroprotective potential of glucose-lowering drugs.
Anna Simanenkova, Oksana Fuks, Natalya Timkina, Alina Islamova, Dina Sufieva, Оlga Kirik, Dmitrii Korzhevskii, Timur Vlasov, Tatiana Karonova   +8 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Peripheral nervous system in limited systemic sclerosis

Reumatismo, 2011
Objectives. PNS is involved in Systemic Sclerosis (SSc) since the earliest phases. Our aim is to perform an ultrastructural study on skin PNS fibers in SSc. Methods.
D. Melchiorre, S. Guiducci, S. Generini, A. Franca Milia, D. Nosi, A. Tani, L. Ibba Manneschi, A. Del Rosso, A. Pignone, M. Matucci Cerinic   +9 more
doaj   +1 more source

The Peripheral Nervous System

, 2017
This chapter focuses on learning the origination and components of the peripheral nervous system and how to draw them. Structures addressed include the neuron, glial cells, neuroglia, neurotransmitters, peripheral nerves, muscle tissues, motor units, and
Adam J Fisch
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Spectrum of the peripheral nervous system involvement in autoimmune hypothyroidism.

, 1998
Atti pubblicati in JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 3: 155, 1998 ...
MESSINA C, VITA G., FAZIO MC, BENVENGA, Salvatore, RODOLICO, Carmelo, TOSCANO A, GIRLANDA, Paolo, LAURA' M   +7 more
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