Molecular Pain, 2016 Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans , responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone
U Anand BSc, MSc, PhD +8 more
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Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]
, 1998 Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F. +1 more
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Functional and immunological peculiarities of peripheral nerve allografts
Neural Regeneration Research, 2022 This review addresses the accumulating evidence that live (not decellularized) allogeneic peripheral nerves are functionally and immunologically peculiar in comparison with many other transplanted allogeneic tissues.
Kelly C.S. Roballo +4 more
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An examination of walking track analysis footprints of right-side unoperated limbs in rats prior to and following peripheral nerve injury and PEG fusion repair [PDF]
, 2018 Peripheral nerve injury can result in long-lasting functional deficits in humans due to mammals’ limited axon regenerative capacity. PEG fusion is a defined technique that fuses injured axons, resulting in morphological and electrophysiological ...
Jagannath, Karthik
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A comparative analysis of manual glenoid version measurement using two- and three-dimensional computed tomography imaging techniques [PDF]
Clinics in Shoulder and ElbowBackground Accurate measurement of glenoid version is essential for optimal implant positioning in shoulder arthroplasty. This study compared the accuracy and reliability of unformatted two-dimensional computed tomography (2D-CT), formatted 2D-CT, and ...
Maxwell S Renna, Ashley I. Simpson
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Frontiers in Chemistry, 2021 Peripheral nerve injury gives rise to devastating conditions including neural dysfunction, unbearable pain and even paralysis. The therapeutic effect of current treatment for peripheral nerve injury is unsatisfactory, resulting in slow nerve regeneration
Shixian Dong +12 more
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Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury [PDF]
, 2015 The goal of this surgical protocol is to expose the facial nerve, which innervates the facial musculature, at its exit from the stylomastoid foramen and either cut or crush it to induce peripheral nerve injury.
Batka, Richard J. +5 more
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The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]
, 2017 The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J. +4 more
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Frontiers in Cellular Neuroscience, 2019 Peripheral Nerve Injury (PNI) is common following blunt or penetrating trauma with an estimated prevalence of 2% among the trauma population. The resulting economic and societal impacts are significant.
Matthew Wilcox +7 more
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Therapeutic Low-Intensity Ultrasound for Peripheral Nerve Regeneration – A Schwann Cell Perspective
Frontiers in Cellular Neuroscience, 2022 Peripheral nerve injuries are common conditions that can arise from trauma (e.g., compression, severance) and can lead to neuropathic pain as well as motor and sensory deficits.
Jenica Acheta +3 more
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