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Nerve Growth Factor and Autoimmune Diseases [PDF]

Current Issues in Molecular Biology, 2023
NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and ...
Sergio Terracina, Giampiero Ferraguti, Luigi Tarani, Francesca Fanfarillo, Paola Tirassa, Massimo Ralli, Giannicola Iannella, Antonella Polimeni, Marco Lucarelli, Antonio Greco, Marco Fiore   +10 more
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Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve [PDF]

Molecular Pain, 2012
Background Cutaneous peripheral neuropathies have been associated with changes of the sensory fiber innervation in the dermis and epidermis. These changes are mediated in part by the increase in local expression of trophic factors.
Peleshok Jennifer C, Ribeiro-da-Silva Alfredo   +1 more
doaj   +2 more sources

Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19 [PDF]

Biology
Neurotrophins (NTs) constitute a family of small protein messengers that play a fundamental role in both the central and peripheral nervous systems. In particular, the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF) play a ...
Carla Petrella, Giampiero Ferraguti, Luigi Tarani, Francesca Tarani, Marisa Patrizia Messina, Marco Fiore   +5 more
doaj   +2 more sources

Nerve growth factor [PDF]

, 1988
Bandtlow, C. E., Heumann, R., Lindholm, D., Meyer, Michael, Rohrer, H., Thoenen, Hans   +5 more
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Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

Cell Communication and Signaling, 2022
Plain English summary Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells ...
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri   +3 more
doaj   +1 more source

Topical delivery of nerve growth factor for treatment of ocular and brain disorders

Neural Regeneration Research, 2021
Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity.
Gemma Eftimiadi, Marzia Soligo, Luigi Manni, Daniela Di Giuda, Maria Lucia Calcagni, Antonio Chiaretti   +5 more
doaj   +1 more source

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
doaj   +1 more source

Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. [PDF]

PLoS ONE, 2013
Nerve growth factor is a neurotrophin that promotes cell growth, differentiation, survival and death through two different receptors: TrkA(NTR) and p75(NTR).
Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofiglio   +8 more
doaj   +1 more source

Nerve Growth Factor Compromise in Down Syndrome

Frontiers in Aging Neuroscience, 2021
The basal forebrain cholinergic system relies on trophic support by nerve growth factor (NGF) to maintain its phenotype and function. In Alzheimer’s disease (AD), basal forebrain cholinergic neurons (BFCNs) undergo progressive atrophy, suggesting a ...
Sonia Do Carmo, Benjamin Kannel, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello   +5 more
doaj   +1 more source

Nerve growth factor and post-infarction cardiac remodeling

Acta Biomedica Scientifica, 2022
The prevalence of sudden death from chronic heart failure and cardiac arrhythmias caused by myocardial infarction is a complex problem in cardiology. Post-infarction cardiac remodeling occurs after myocardial infarction.
O. Yu. Kytikova, T. P. Novgorodtseva, М. V. Antonyuk, Yu. K. Denisenko, O. V. Atamas   +4 more
doaj   +1 more source