Results 11 to 20 of about 9,223,748 (201)

Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain

Therapeutics and Clinical Risk Management, 2017
Xiushuai Shang, Zhaofei Wang, Hairong Tao Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China Abstract: Osteoarthritis
Shang X, Wang Z, Tao H
doaj   +1 more source

Effcacy and safety of nerve growth factor for the treatment of neurological diseases: a meta-analysis of 64 randomized controlled trials involving 6,297 patients

Neural Regeneration Research, 2015
OBJECTIVE: China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug.
Meng Zhao, Xiao-yan Li, Chun-ying Xu, Li-ping Zou   +3 more
doaj   +1 more source

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2021
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato, Giovanni Galasso, Pia Giovannelli, Antonio A. Sinisi, Antimo Migliaccio, Gabriella Castoria   +5 more
doaj   +1 more source

Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay [PDF]

, 2007
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels.
Lionel Bueno, Ferrier, Laurent, Fioramonti, Jean, Mathilde Leveque, Cartier, Christel, Frederick Barreau, Raphael Moriez, Valerie Laroute, Laurent Ferrier, Andras Rosztoczy, Christel Cartier, Leveque, Mathilde, Rosztoczy, Andras, Jean Fioramonti, Barreau, Frederick, Laroute, Valerie, Moriez, Raphael, Bueno, Lionel, Leveque, M, Rosztoczy, A, Ferrier, L   +20 more
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Exogenous nerve growth factor protects the hypoglossal nerve against crush injury

Neural Regeneration Research, 2015
Studies have shown that sensory nerve damage can activate the p38 mitogen-activated protein kinase (MAPK) pathway, but whether the same type of nerve injury after exercise activates the p38MAPK pathway remains unclear.
Li-yuan Fan, Zhong-chao Wang, Pin Wang, Yu-yan Lan, Ling Tu   +4 more
doaj   +1 more source

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats

Brazilian Journal of Otorhinolaryngology, 2023
Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.
Aracele Gonçalves Vieira, Fausto Pierdona Guzen, José Rodolfo Lopes de Paiva, Lucídio Clebeson de Oliveira, Maria Clara de Araújo Jales, Eudes Euler de Souza Lucena, Virgínia Raquel dos Santos Lucena, Hécio Henrique Araújo de Morais   +7 more
doaj   +1 more source

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A., Reynolds, Paul Andrew; id_orcid, Gunn-Moore, Frank J; id_orcid   +47 more
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Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

BMC Musculoskeletal Disorders, 2019
Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients.
Shotaro Takano, Kentaro Uchida, Makoto Itakura, Dai Iwase, Jun Aikawa, Gen Inoue, Manabu Mukai, Masayuki Miyagi, Kosuke Murata, Hiroyuki Sekiguchi, Masashi Takaso   +10 more
doaj   +1 more source

Nerve growth factor, mast cells and arthritis [PDF]

, 1995
Nerve growth factor is a well-characterized neurotrophic protein required for the survival and differentiation of a variety of neuronal cell types both in the peripheral and central nervous systems.
Aloe, Luigi; National Research Council of Rome, Tuveri, Marco Aurelio; National Research Council of Rome, Angelucci, Francesco; National Research Council of Rome   +2 more
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Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects

Neural Regeneration Research, 2023
Studies have shown that human hair keratin (HHK) has no antigenicity and excellent mechanical properties. Schwann cells, as unique glial cells in the peripheral nervous system, can be induced by interleukin-1β to secrete nerve growth factor, which ...
Han-Jun Qin, Hang Li, Jun-Ze Chen, Kai-Rui Zhang, Xing-Qi Zhao, Jian-Qiang Qin, Bin Yu, Jun Yang   +7 more
doaj   +1 more source