Results 11 to 20 of about 503,486 (309)

Nerve Growth Factor Suppresses Prostate Tumor Growth

open access: yesJournal of Pharmacological Sciences, 2010
Nerve growth factor (NGF) facilitates reinnervation of perivascular nerves that regulate vascular tone and blood flow. This study investigated whether NGF prevents tumor growth by promoting neuronal regulation of tumor blood flow.
Mitsuhiro Goda   +5 more
doaj   +1 more source

Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

open access: yesNeural Regeneration Research, 2015
Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component ...
Bo Chen   +9 more
doaj   +1 more source

Enhancement of sciatic nerve regeneration with dual delivery of vascular endothelial growth factor and nerve growth factor genes

open access: yesJournal of Nanobiotechnology, 2020
Background Peripheral nerve injury is one common clinical disease worldwide, in which sciatic nerve is anatomically the most challenging to regenerate given its length and large cross-sectional area.
Zhiwei Fang   +5 more
doaj   +1 more source

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

open access: yesFrontiers in Cell and Developmental Biology, 2021
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato   +5 more
doaj   +1 more source

Effcacy and safety of nerve growth factor for the treatment of neurological diseases: a meta-analysis of 64 randomized controlled trials involving 6,297 patients

open access: yesNeural Regeneration Research, 2015
OBJECTIVE: China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug.
Meng Zhao   +3 more
doaj   +1 more source

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]

open access: yes, 2017
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De   +9 more
core   +1 more source

Exogenous nerve growth factor protects the hypoglossal nerve against crush injury

open access: yesNeural Regeneration Research, 2015
Studies have shown that sensory nerve damage can activate the p38 mitogen-activated protein kinase (MAPK) pathway, but whether the same type of nerve injury after exercise activates the p38MAPK pathway remains unclear.
Li-yuan Fan   +4 more
doaj   +1 more source

Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial. [PDF]

open access: yes, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite extension through chondroitin sulfate-rich matrices and
Butterfield, Karen Chao   +2 more
core   +1 more source

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats

open access: yesBrazilian Journal of Otorhinolaryngology, 2023
Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.
Aracele Gonçalves Vieira   +7 more
doaj   +1 more source

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

open access: yes, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A.   +5 more
core   +2 more sources

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