Results 41 to 50 of about 185,165 (275)

The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]

open access: yes, 2016
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core   +1 more source

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

open access: yes, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M.   +7 more
core   +1 more source

Depression, Neuroplasticity and Neurotrophic Factors [PDF]

open access: yesPsikiyatride Güncel Yaklaşımlar, 2009
Depression is a common psychiatric disorder. There is still very little known about the neurobiological alterations that underlie the pathophysiology of depression.
Cengiz Akkaya   +3 more
doaj  

Grafts of Fibroblasts Genetically Modified to Secrete Ngf, Bdnf, Nt-3, or Basic Fgf Elicit Differential Responses in the Adult Spinal Cord

open access: yesCell Transplantation, 1996
Neuronal and axonal responses to neurotrophic factors in the developing spinal cord have been relatively well characterized, but little is known about adult spinal responses to neurotrophic factors.
Yasushi Nakahara   +2 more
doaj   +1 more source

A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise

open access: yesScientific Reports, 2021
Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime ...
Dreu White   +11 more
doaj   +1 more source

Neurotrophic keratitis in a patient with disseminated lymphangiomatosis. [PDF]

open access: yes, 2009
INTRODUCTION: Neurotrophic keratitis, a degenerative corneal disease caused by trigeminal nerve impairment, has many etiologies and remains very difficult to treat.
Charukamnoetkanok, Puwat   +2 more
core   +2 more sources

The immediate early gene Egr3 Is required for hippocampal induction of Bdnf by electroconvulsive stimulation [PDF]

open access: yes, 2018
Early growth response 3 (Egr3) is an immediate early gene (IEG) that is regulated downstream of a cascade of genes associated with risk for psychiatric disorders, and dysfunction of Egr3 itself has been implicated in schizophrenia, bipolar disorder, and ...
Brunwasser, Samuel J   +6 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. [PDF]

open access: yesPLoS ONE, 2015
PURPOSE:The skeletal muscle develops various degrees of atrophy and metabolic dysfunction following nerve injury. Neurotrophic factors are essential for muscle regeneration.
Chun-Jung Chen   +8 more
doaj   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

open access: yes, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Plate, Karl H.   +2 more
core   +1 more source

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