Results 41 to 50 of about 7,894,191 (193)

Polydopamine-modified chitin conduits with sustained release of bioactive peptides enhance peripheral nerve regeneration in rats

open access: yesNeural Regeneration Research, 2022
[INLINE:1] The introduction of neurotrophic factors into injured peripheral nerve sites is beneficial to peripheral nerve regeneration. However, neurotrophic factors are rapidly degraded in vivo and obstruct axonal regeneration when used at a ...
Ci Li   +7 more
doaj   +1 more source

Neurotrophic factors and their effects in the treatment of multiple sclerosis

open access: yesAdvanced Biomedical Research, 2015
Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration,
Shahnaz Razavi   +5 more
doaj   +1 more source

Delta Secretase and BDNF Signalling in Alzheimer’s Disease

open access: yesExperimed, 2023
As one of the major contributors of the central nervous system, neurons require neurotrophic factors, which are synthesized from neighbouring cells, for several cellular processes, such as neuronal survival, growth, and differentiation.
Buse Ünlü   +3 more
doaj   +1 more source

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease. [PDF]

open access: yes, 2017
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson’s disease.
Hegarty, Shane V.   +2 more
core   +1 more source

Neurotrophic Factors in Multiple Sclerosis: a Review of the Mechanism [PDF]

open access: yesNeurology Letters
The objective of this review is to examine the mechanistic roles of neurotrophic factors (NTFs) in the pathology of multiple sclerosis (MS) and their potential as therapeutic agents. MS is a chronic autoimmune disease of the central nervous system (CNS),
Samaneh Azizpour, Vahid Moghadasi
doaj   +1 more source

Changes in Neurotrophic Factors of Adult Rat Laryngeal Muscles During Nerve Regeneration

open access: yes, 2016
Injury to the recurrent laryngeal nerve (RLN) leads to the loss of ipsilateral laryngeal fold movement, with dysphonia, and occasionally dysphagia.
Hernandez-Morato, Ignacio   +2 more
core   +1 more source

Grafts of Fibroblasts Genetically Modified to Secrete Ngf, Bdnf, Nt-3, or Basic Fgf Elicit Differential Responses in the Adult Spinal Cord

open access: yesCell Transplantation, 1996
Neuronal and axonal responses to neurotrophic factors in the developing spinal cord have been relatively well characterized, but little is known about adult spinal responses to neurotrophic factors.
Yasushi Nakahara   +2 more
doaj   +1 more source

A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise

open access: yesScientific Reports, 2021
Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime ...
Dreu White   +11 more
doaj   +1 more source

RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]

open access: yes, 2013
Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
core  

Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. [PDF]

open access: yesPLoS ONE, 2015
PURPOSE:The skeletal muscle develops various degrees of atrophy and metabolic dysfunction following nerve injury. Neurotrophic factors are essential for muscle regeneration.
Chun-Jung Chen   +8 more
doaj   +1 more source

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