Results 41 to 50 of about 124,933 (262)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

Peripheral biomarkers in bipolar disorder manic episode

open access: yesPsychiatry and Behavioral Sciences, 2017
Bipolar disorder is a chronic illness of which the etiology is not fully elucidated. Recently, in order to understand the pathophysiogy of bipolar disorder, oxidative stress, inflammation, and neurotrophic factors have been widely studied. Although there
Abdullah Genc   +2 more
doaj   +1 more source

Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

open access: yesBiomolecules, 2022
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau ...
Narjes Baazaoui, Khalid Iqbal
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

open access: yesArthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni   +7 more
wiley   +1 more source

Effect of selegiline on neural stem cells differentiation: a possible role for neurotrophic factors [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2015
Objective(s): The stimulation of neural stem cells (NSCs) differentiation into neurons has attracted great attention in management of neurodegenerative disease and traumatic brain injury. It has been reported that selegiline could enhance the morphologic
Kambiz Hassanzadeh   +3 more
doaj  

Neurotrophic factors in the testis

open access: yes, 1999
Neurotrophic factors, interacting with neurons to affect their growth, are a subset of the polypeptide growth factors. There is increasing evidence for a broader physiological role of these factors which includes effects on a variety of nonneuronal ...
Davidoff, Michail S.; University of Hamburg   +2 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

open access: yesAdvanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Cross‐talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors

open access: yesPhysiological Reports, 2021
Neuromuscular junction (NMJ) research is vital to advance the understanding of neuromuscular patho‐physiology and development of novel therapies for diseases associated with NM dysfunction.
Jasdeep Saini   +8 more
doaj   +1 more source

EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS

open access: yesФармация и фармакология (Пятигорск), 2021
The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya   +5 more
doaj   +1 more source

Neurotrophic factors and their receptors

open access: yes, 1994
Development of the nervous system depends on signals that instruct neurons when to divide, differentiate, survive, or die. There are now two known distinct classes of factors noted for their neurotrophic activities—the family of factors collectively ...
Ip, Nancy Y., Yancopoulos, George D.
core   +1 more source

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