Results 61 to 70 of about 7,894,191 (193)

Preclinical Testing of Neuroprotective Neurotrophic Factors in a Model of Chronic Motor Neuron Degeneration

open access: yesNeurobiology of Disease, 1999
Many neurotrophic factors have been shown to enhance survival of embryonic motor neurons or affect their response to injury. Few studies have investigated the potential effects of neurotrophic factors on more mature motor neurons that might be relevant ...
Andrea M. Corse   +5 more
doaj   +1 more source

Hippocampal neurogenesis and antidepressive therapy: shocking relations. [PDF]

open access: yes, 2014
Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago.
Aigner, Ludwig   +15 more
core   +1 more source

Neurotrophic Factors in Neurodegeneration

open access: yesBrain Pathology, 2006
Neurotrophic factors (NTFs) have the unique potential to support neuronal survival and to augment neuronal function in the injured and diseased nervous system. Numerous studies conducted over the last 20 years have provided evidence for the potent therapeutic potential of NTFs in animal models of neurodegenerative diseases. However, major obstacles for
openaire   +3 more sources

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes

open access: yesBrain Sciences, 2019
(1) Background: Dimethylfumarate (DMF) has been approved for the treatment of relapsing remitting multiple sclerosis. However, the mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood ...
Kaweh Pars   +8 more
doaj   +1 more source

Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: A signaling response mediated by estrogen receptor [PDF]

open access: yes, 2013
Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders.
Bi, Cathy W.C.   +6 more
core   +1 more source

Neurotrophic factors: important regulators of nociceptive function.

open access: yes, 2016
Neurotrophic factors have an established developmental role in regulating the survival and specification of sensory neurons. However, these factors continue to exert an important influence on sensory neurons throughout the postnatal period and into adult

core   +1 more source

Enteric nervous system: Neurotrophic factors

open access: yes, 2009
The enteric nervous system (ENS) is the most complex region of the peripheral nervous system. The roles of neurotrophic factors in the early development of the ENS are relatively well established.
Saffrey, Jill, M.J. Saffrey
core   +1 more source

Molecular evolution of brain-derived neurotrophic factors.

open access: yes, 2013
Three-dimensional homology models of brain-derived neurotrophic factors (BDNF), depicting the molecular evolution of these non-venomous homologues. The ω values (Model 8) for the respective taxa (PP ≥ 0.95, Bayes-Empirical Bayes approach) are indicated.
Nicolas Vidal (377180)   +10 more
core   +1 more source

Impact of neurotrophic factors combination therapy on retinitis pigmentosa

open access: yesJournal of International Medical Research, 2020
Objective We aimed to determine the location of neurotrophic receptors tropomyosin receptor kinase (Trk)B, TrkC, and ciliary neurotrophic factor receptor (CNTFR)α in the retina of retinal degeneration ( rd ) mice and to explore the dynamic changes of B ...
Xiaobei Yin   +4 more
doaj   +1 more source

Elaphuri Davidiani Cornu Improves Depressive-Like Behavior in Mice and Increases Neurotrophic Factor Expression in Mouse Primary Astrocytes via cAMP and ERK-Dependent Pathways

open access: yesFrontiers in Pharmacology, 2020
Elaphuri Davidiani Cornu (EDC) is the natural shedding horn of Elaphurus davidiauus Millne-Edwards that was used by people in ancient China for maintaining physical and mental health.
Yue Zhu   +11 more
doaj   +1 more source

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