Results 61 to 70 of about 7,532,121 (298)

Preclinical Testing of Neuroprotective Neurotrophic Factors in a Model of Chronic Motor Neuron Degeneration

Neurobiology of Disease, 1999
Many neurotrophic factors have been shown to enhance survival of embryonic motor neurons or affect their response to injury. Few studies have investigated the potential effects of neurotrophic factors on more mature motor neurons that might be relevant ...
Andrea M. Corse, Masako M. Bilak, Stephan R. Bilak, Mohamed Lehar, Jeffrey D. Rothstein, Ralph W. Kuncl   +5 more
doaj   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Associations between brain-derived neurotrophic factor plasma levels and severity of the illness, recurrence and symptoms in depressed patients. [PDF]

, 2010
Background: There is an increasing evidence that the Brain-Derived Neurotrophic Factor (BDNF) could be involved in the pathophysiology of mood disorders and that its peripheral levels may represent a reliable mirror of its concentration in the brain. The
BIANCHI, CAROLINA
core  

Enteric nervous system: Neurotrophic factors

, 2009
The enteric nervous system (ENS) is the most complex region of the peripheral nervous system. The roles of neurotrophic factors in the early development of the ENS are relatively well established.
Saffrey, Jill, M.J. Saffrey
core   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes

Brain Sciences, 2019
(1) Background: Dimethylfumarate (DMF) has been approved for the treatment of relapsing remitting multiple sclerosis. However, the mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood ...
Kaweh Pars, Marina Gingele, Jessica Kronenberg, Chittappen K Prajeeth, Thomas Skripuletz, Refik Pul, Roland Jacobs, Viktoria Gudi, Martin Stangel   +8 more
doaj   +1 more source

AMSCs secreted neurotrophic factors in vitro.

, 2022
The ability of AMSCs to secrete trophic factors was evaluated using ELISA. Neurotrophic factors such as (A) BDNF, (B) VEGF, and (C) b-FGF were significantly secreted from AMSCs compared with the control medium.
Sho Yamaguchi (5309186), Shunsuke Ohnishi (167269), Masahito Kawabori (13021466), Kazuyoshi Yamazaki (7387250), Toshitaka Seki (13021472), Kotaro Konno (534026), Khin Khin Tha (13021475), Miki Fujimura (7244756), Koji Yamamoto (505190), Soichiro Takamiya (13021463), Kiyohiro Houkin (562861), Aki Tanimori (13021469), Daigo Hashimoto (13021478), Masahiko Watanabe (47746)   +13 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Neurotrophic factors and hippocampal activity in PTSD. [PDF]

PLoS ONE, 2018
Although numerous studies have investigated the neurotrophic factors and hippocampal activity in posttraumatic stress disorder (PTSD) separately each other, it is unclear whether an association between neurotrophic factors and hippocampal activity is ...
Ümit Tural, Ahmet Tamer Aker, Emin Önder, Hatice Turan Sodan, Hatice Ünver, Gür Akansel   +5 more
doaj   +1 more source