Results 1 to 10 of about 34,905 (242)
GDNF and alcohol use disorder [PDF]
Addiction Biology, 2018 AbstractGlial cell line‐derived neurotrophic factor (GDNF) has been extensively studied for its role in the development and maintenance of the midbrain dopaminergic system, although evidence suggests that GDNF also plays a role in drug and alcohol addiction. This review focuses on the unique actions of GDNF in the mechanisms that prevent the transition
Segev Barak +3 more
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Frontiers in Neuroanatomy, 2015 The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of neuronal morphological and neurochemical phenotype and protects DA neurons
Xavier ed'Anglemont De Tassigny +7 more
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Frontiers in Neurology, 2018 Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-region.
Ilmari Parkkinen +2 more
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Neurobiology of Disease, 2006 The effect of selective injury to dopaminergic neurons on the expression of glial cell line-derived neurotrophic factor (GDNF) was examined in substantia nigra cell cultures.
Graça Baltazar, Emilia P Duarte
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Functional Analysis of Zebrafish GDNF
Developmental Biology, 2001 We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have identified areas of correlated ...
Shepherd, Iain T. +2 more
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GDNF and GFRα1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons
Cell Reports, 2019 Summary: The glial cell line-derived neurotrophic factor (GDNF) is required for the survival and differentiation of diverse neuronal populations during nervous system development.
Antonela Bonafina +2 more
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Insight into the role of GDNF and the GDNF family of receptors in glioblastoma
Glioblastoma is the most aggressive and the most common type of primary brain cancer, and despite treatment consisting of surgical tumor removal, radiotherapy and chemotherapy, glioblastoma patients have a poor prognosis with a median survival of 15 months and a five-year survival of 5-7 %.
Ewald, Jesper Dupont; id_orcid
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GDNF expression during Xenopus development
Gene Expression Patterns, 2007 Glial cell line-derived neurotrophic factor (GDNF) has multiple roles in kidney morphogenesis, spermatogenesis, and neurogenesis during development. In this study, we report the cloning and expression pattern of Xenopus laevis GDNF. The X. laevis GDNF cDNA sequence has a complete open reading frame of 684 bases, predicting 227 amino acid residues at ...
Jun-ichi, Kyuno, Elizabeth A, Jones
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Cancer Biology & Medicine, 2021 Objective: Because of the poor prognosis of lacrimal adenoid cystic carcinoma (LACC), we aimed to investigate the effects of perineural invasion (PNI) and consequent aberrations in GDNF/GFRα-1/RET protein expression on LACC recurrence.
Lin Liu +5 more
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Polish Journal of Pathology, 2020 Here we review the role of GDNF, PTCH1, RNF213 illustrated by a case of renal cell carcinoma, chromophobe type (pT2a 8th pTNM edition) of the left kidney of 71-year-old man.
Artur Kowalik +8 more
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