Results 1 to 10 of about 1,085 (68)
Frontiers in Neurology, 2018 Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-region.
Raimo K Tuominen +2 more
exaly +3 more sources
Frontiers in Neuroanatomy, 2015 The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of neuronal morphological and neurochemical phenotype and protects DA neurons
Alberto Pascual +2 more
exaly +3 more sources
Cancer Biology & Medicine, 2021 Objective: Because of the poor prognosis of lacrimal adenoid cystic carcinoma (LACC), we aimed to investigate the effects of perineural invasion (PNI) and consequent aberrations in GDNF/GFRα-1/RET protein expression on LACC recurrence.
Lin Liu +5 more
doaj +1 more source
Polish Journal of Pathology, 2020 Here we review the role of GDNF, PTCH1, RNF213 illustrated by a case of renal cell carcinoma, chromophobe type (pT2a 8th pTNM edition) of the left kidney of 71-year-old man.
Artur Kowalik +8 more
doaj +1 more source
The GDNF System Is Altered in Diverticular Disease - Implications for Pathogenesis. [PDF]
PLoS ONE, 2013 Absence of glial cell line-derived neurotrophic factor (GDNF) leads to intestinal aganglionosis. We recently demonstrated that patients with diverticular disease (DD) exhibit hypoganglionosis suggesting neurotrophic factor deprivation.
Martina Böttner +8 more
doaj +1 more source
Neural Regeneration Research, 2021 Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the protection of dopaminergic neurons, but there are few reports of the relationship between GDNF and its precursors (α-pro-GDNF and β-pro-GDNF) and cognitive impairment in ...
Ming-Yu Shi +7 more
doaj +1 more source
Neural Regeneration Research, 2020 Glial cell line-derived neurotrophic factor (GDNF) plays a critical role in neuronal survival and function. GDNF has two major splice variants in the brain, α-pro-GDNF and β-pro-GDNF, and both isoforms have strong neuroprotective effects on dopamine ...
Xiao-He Gu +6 more
doaj +1 more source
Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes. [PDF]
PLoS ONE, 2011 BACKGROUND AND AIMS: In mammalian spermatogenesis, glial cell line-derived neurotrophic factor (GDNF) is one of the major Sertoli cell-derived factors which regulates the maintenance of undifferentiated spermatogonia including spermatogonial stem cells ...
Takeshi Sato +19 more
doaj +1 more source
GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signalling. [PDF]
PLoS ONE, 2009 The glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for several neuronal populations in different brain regions, including the hippocampus. However, no information is available on the: (1) hippocampal subregions involved in
Francesca Boscia +5 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2023 Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients.
Marcelo Duarte Azevedo +10 more
doaj +1 more source