Results 11 to 20 of about 34,905 (242)
The GDNF System Is Altered in Diverticular Disease - Implications for Pathogenesis. [PDF]
PLoS ONE, 2013 Absence of glial cell line-derived neurotrophic factor (GDNF) leads to intestinal aganglionosis. We recently demonstrated that patients with diverticular disease (DD) exhibit hypoganglionosis suggesting neurotrophic factor deprivation.
Martina Böttner +8 more
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Neural Regeneration Research, 2021 Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the protection of dopaminergic neurons, but there are few reports of the relationship between GDNF and its precursors (α-pro-GDNF and β-pro-GDNF) and cognitive impairment in ...
Ming-Yu Shi +7 more
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Neural Regeneration Research, 2020 Glial cell line-derived neurotrophic factor (GDNF) plays a critical role in neuronal survival and function. GDNF has two major splice variants in the brain, α-pro-GDNF and β-pro-GDNF, and both isoforms have strong neuroprotective effects on dopamine ...
Xiao-He Gu +6 more
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Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes. [PDF]
PLoS ONE, 2011 BACKGROUND AND AIMS: In mammalian spermatogenesis, glial cell line-derived neurotrophic factor (GDNF) is one of the major Sertoli cell-derived factors which regulates the maintenance of undifferentiated spermatogonia including spermatogonial stem cells ...
Takeshi Sato +19 more
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تأثیر چهار هفته تمرین هوازی بر بیان ژن فاکتور تغذیهای مشتقشده از سلولهای گلیال، TNF-α و عوامل شناختی در هیپوکمپ رتهای مبتلا به بیماری آلزایمر القاشده با آمیلویید بتا [PDF]
فیزیولوژی ورزشی, 2021 زمینه و هدف : بیماری آلزایمر شایعترین شکل زوال عقل است و آمیلوئیدبتا نقشی در بیماری زایی آن ایفا میکنند. در سالهای اخیر ورزش منظم به عنوان یکی از سازوکارهای غیردارویی مهم برای مقابل با بیماری آلزایمر مطرح شده است.
پیمان قاسمی +3 more
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Molecular Therapy: Methods & Clinical Development, 2023 Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients.
Marcelo Duarte Azevedo +10 more
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GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signalling. [PDF]
PLoS ONE, 2009 The glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for several neuronal populations in different brain regions, including the hippocampus. However, no information is available on the: (1) hippocampal subregions involved in
Francesca Boscia +5 more
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Офтальмохирургия, 2022 Purpose. To evaluate content of glial-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with primary open-angle glaucoma (POAG) and age-related cataract. Material and methods.
A.A. Troshina +4 more
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Molecular Therapy: Methods & Clinical Development, 2020 Glial cell line-derived neurotrophic factor (GDNF) supports function and survival of dopamine neurons that degenerate in Parkinson’s disease (PD). Ectopic delivery of GDNF in clinical trials to treat PD is safe but lacks significant therapeutic effect ...
Giorgio Turconi +6 more
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Adenoviral-mediated glial cell line-derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury. [PDF]
PLoS ONE, 2014 Neuropathic pain due to peripheral nerve injury may be associated with abnormal central nerve activity. Glial cell-line-derived neurotrophic factor (GDNF) can help attenuate neuropathic pain in different animal models of nerve injury.
An-Kuo Chou +6 more
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