Results 11 to 20 of about 37,648 (242)
Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice [PDF]
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +2 more sources
GDNF and alcohol use disorder [PDF]
Addiction Biology, 2018 AbstractGlial cell line‐derived neurotrophic factor (GDNF) has been extensively studied for its role in the development and maintenance of the midbrain dopaminergic system, although evidence suggests that GDNF also plays a role in drug and alcohol addiction. This review focuses on the unique actions of GDNF in the mechanisms that prevent the transition
Segev Barak +3 more
openaire +6 more sources
Open Chemistry, 2020 This study aims to prepare ultrasound-targeted glial cell-derived neurotrophic factor (GDNF) retrovirus-loaded microbubbles (M pLXSN-GDNF) to verify the properties of the microbubbles and to study the therapeutic effect of the GDNF retrovirus-loaded ...
Wang Feng +11 more
doaj +2 more sources
The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology [PDF]
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario +3 more
wiley +2 more sources
Glial cell line-derived neurotrophic factor effects on dental pulp cells and osteoblast-like cells [PDF]
, 2012 Glial cell line-derived neurotrophic factor (GDNF) is a growth factor promoting survival, proliferation and differentiation of neural crest cells. Neural crest cells play an important role within mesenchymal tissues during dental pulp and calvarial bone ...
Gale, Zoe
core +7 more sources
Офтальмохирургия, 2022 Purpose. To evaluate content of glial-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with primary open-angle glaucoma (POAG) and age-related cataract. Material and methods.
A.A. Troshina +4 more
doaj +1 more source
A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies [PDF]
, 2021 We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined with brain-derived neurotrophic factor (BDNF ...
Fernández Robredo, Patricia +31 more
core +1 more source
Adenoviral-mediated glial cell line-derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury. [PDF]
PLoS ONE, 2014 Neuropathic pain due to peripheral nerve injury may be associated with abnormal central nerve activity. Glial cell-line-derived neurotrophic factor (GDNF) can help attenuate neuropathic pain in different animal models of nerve injury.
An-Kuo Chou +6 more
doaj +1 more source
PLoS Genetics, 2015 Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has ...
Anmol Kumar +23 more
doaj +1 more source
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]
, 2007 Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu +32 more
core +2 more sources