Results 21 to 30 of about 34,905 (242)
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]
, 2007 Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu +27 more
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PLoS Genetics, 2015 Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has ...
Anmol Kumar +23 more
doaj +1 more source
Brain Sciences, 2023 Sleep disturbances are the most prevalent non-motor symptoms in the preclinical stage of Parkinson’s disease (PD). Adenosine, glial-derived neurotrophic factor (GDNF), and associated neurotransmitters are crucial in the control of sleep arousal.
Li Wang +4 more
doaj +1 more source
, 2021 We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined with brain-derived neurotrophic factor (BDNF ...
Fernández Robredo, Patricia +25 more
core +1 more source
SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET
Cell Reports, 2013 Glial cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that has reached clinical trials for Parkinson’s disease. GDNF binds to its coreceptor GFRα1 and signals through the transmembrane receptor tyrosine kinase RET, or RET ...
Simon Glerup +13 more
doaj +1 more source
Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits [PDF]
, 2017 Local long-term delivery of glial cell line derived neurotrophic factor (GDNF) from vitamin E/poly-lactic-co-glycolic acid microspheres (MSs) protects retinal ganglion cells in an animal model of glaucoma for up to 11 weeks. However, the pharmacokinetics
Prieto Calvo, Esther +26 more
core +1 more source
Drug Design, Development and Therapy, 2020 Yahan Zhang,1 Qiushi Gao,1 Ziyi Wu,1 Hang Xue,1 Bo Liu,2 Ping Zhao1 1Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, People’s Republic of China; 2Department of Animal Laboratory of Experimental Research Center,
Zhang Y +5 more
doaj
The Noradrenergic System of Aged GDNF Heterozygous Mice
Cell Transplantation, 2003 Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for noradrenergic (NE) neurons of the pontine nucleus locus coeruleus (LC).
V. Zaman +9 more
doaj +1 more source
Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation [PDF]
Neurology, 2013 We previously reported clinical improvement, increase in putamen [(18)F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic fibers following chronic intraputaminal delivery of glial cell line-derived neurotrophic factor (GDNF) in idiopathic Parkinson disease (PD).(1-3) We now provide clinical and PET evidence of ...
Patel, Nikunj K +5 more
openaire +2 more sources
A regulatable adenovector system for GDNF and GFP delivery in the rat hippocampus
, 2020 Spatial memory performance declines in both normal aging and Alzheimer's disease. This cognitive deficit is related to hippocampus dysfunction. Gene therapy using neurotrophic factors like Glial cell line-derived neurotrophic factor (GDNF) emerges as a ...
Coll, Lucia +3 more
core +1 more source