Results 31 to 40 of about 37,648 (242)

The Noradrenergic System of Aged GDNF Heterozygous Mice

Cell Transplantation, 2003
Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for noradrenergic (NE) neurons of the pontine nucleus locus coeruleus (LC).
V. Zaman, Z. Li, L. Middaugh, S. Ramamoorthy, B. Rohrer, M. E. Nelson, A. C. Tomac, B. J. Hoffer, G. A. Gerhardt, A. Ch. Granholm DR.   +9 more
doaj   +1 more source

Enhanced therapeutic potential of paeoniflorin and vitamin B12 in intracerebropeduncle ethidium bromide-induced multiple sclerosis-like pathology

Frontiers in Pharmacology
The study investigates the neuroprotective potential of paeoniflorin (PNN) in mitigating the multifaceted pathology of multiple sclerosis (MS) in an ethidium bromide-induced (EBRO) rat model. A comprehensive approach utilizing in silico, in-vitro, and in-
MD Nasiruddin Khan, Sidharth Mehan, Divya Choudhary, Ravi Rana, Ghanshyam Das Gupta, Acharan S. Narula   +5 more
doaj   +1 more source

Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson’s Disease

Journal of Parkinson’s Disease, 2019
Background: Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson’s disease, did not show significant clinical improvements against placebo at 40 weeks, although it ...
Alan L. Whone, Mihaela Boca, Matthias Luz, Max Woolley, Lucy Mooney, Sonali Dharia, Jack Broadfoot, David Cronin, Christian Schroers, Neil U. Barua, Lara Longpre, C. Lynn Barclay, Chris Boiko, Greg A. Johnson, H. Christian Fibiger, Rob Harrison, Owen Lewis, Gemma Pritchard, Mike Howell, Charlie Irving, David Johnson, Suk Kinch, Christopher Marshall, Andrew D. Lawrence, Stephan Blinder, Vesna Sossi, A. Jon Stoessl, Paul Skinner, Erich Mohr, Steven S. Gill   +29 more
doaj   +1 more source

The pre-teatment effect of voluntary exercise by GDNF on lesion injectioned by 6- hydroxydopamine in brain stem of male rats Abstract [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2014
Background&Purpose: The purpose of this research was to investigate the protective effect of voluntary exercise by GDNF on lesion induced by 6-hydroxydopamine in brainstem of male rats.
راضیه محمدی, ضیاء فلاح محمدی, خدیجه آقاجانی, ابواقاسم تقوی هلق   +3 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST? [PDF]

, 2005
PURPOSE: We previously demonstrated that exogenous glial cell line-derived neurotrophic factor (GDNF) induces histological and functional protection of photoreceptors in the retinal degeneration (rd1) mouse model.
Neveux, N, Leveillard, T, Sahel, JA, Simonutti, M, Delyfer, MN   +4 more
core  

Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

Neurobiology of Disease, 2009
In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astrocytes
Jagdeep K. Sandhu, Mossa Gardaneh, Rafal Iwasiow, Patricia Lanthier, Sandhya Gangaraju, Maria Ribecco-Lutkiewicz, Roger Tremblay, Kazutoshi Kiuchi, Marianna Sikorska   +8 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Regulating GDNF expression using DD.

, 2013
(A) Histogram showing the levels of GDNF produced from DD-YFP vector, wild type GDNF, GDNF-DD and DD-GDNF, as measured by GDNF ELISA. C-terminal fusion of the DD to GDNF did not result in any GDNF production, while N-terminal DD-GDNF fusion resulted in ...
Khalid Tai (304854), Fredrik Gussing (304857), Christina Isaksson (304856), Cecilia Lundberg (228364), Luis Quintino (304855)   +4 more
core   +1 more source

Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation [PDF]

Neurology, 2013
We previously reported clinical improvement, increase in putamen [(18)F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic fibers following chronic intraputaminal delivery of glial cell line-derived neurotrophic factor (GDNF) in idiopathic Parkinson disease (PD).(1-3) We now provide clinical and PET evidence of ...
Patel, Nikunj K, Pavese, Nicola; id_orcid 0000-0002-6801-6194, Javed, Shazia, Hotton, Gary R, Brooks, David J; id_orcid 0000-0003-2602-2518, Gill, Steven S   +5 more
openaire   +2 more sources