Results 31 to 40 of about 34,905 (242)

Enhanced therapeutic potential of paeoniflorin and vitamin B12 in intracerebropeduncle ethidium bromide-induced multiple sclerosis-like pathology

Frontiers in Pharmacology
The study investigates the neuroprotective potential of paeoniflorin (PNN) in mitigating the multifaceted pathology of multiple sclerosis (MS) in an ethidium bromide-induced (EBRO) rat model. A comprehensive approach utilizing in silico, in-vitro, and in-
MD Nasiruddin Khan, Sidharth Mehan, Divya Choudhary, Ravi Rana, Ghanshyam Das Gupta, Acharan S. Narula   +5 more
doaj   +1 more source

Treatment of Parkinson’s disease using focused ultrasound with GDNF retrovirus-loaded microbubbles to open the blood–brain barrier

Open Chemistry, 2020
This study aims to prepare ultrasound-targeted glial cell-derived neurotrophic factor (GDNF) retrovirus-loaded microbubbles (M pLXSN-GDNF) to verify the properties of the microbubbles and to study the therapeutic effect of the GDNF retrovirus-loaded ...
Wang Feng, Li Nana, Hou Ruanling, Wang Lu, Zhang Libin, Li Chenzhang, Zhang Yu, Yin Yaling, Chang Liansheng, Cheng Yuan, Wang Yongling, Lu Jianping   +11 more
doaj   +1 more source

Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson’s Disease

Journal of Parkinson’s Disease, 2019
Background: Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson’s disease, did not show significant clinical improvements against placebo at 40 weeks, although it ...
Alan L. Whone, Mihaela Boca, Matthias Luz, Max Woolley, Lucy Mooney, Sonali Dharia, Jack Broadfoot, David Cronin, Christian Schroers, Neil U. Barua, Lara Longpre, C. Lynn Barclay, Chris Boiko, Greg A. Johnson, H. Christian Fibiger, Rob Harrison, Owen Lewis, Gemma Pritchard, Mike Howell, Charlie Irving, David Johnson, Suk Kinch, Christopher Marshall, Andrew D. Lawrence, Stephan Blinder, Vesna Sossi, A. Jon Stoessl, Paul Skinner, Erich Mohr, Steven S. Gill   +29 more
doaj   +1 more source

Three-Dimensional Model of Dorsal Root Ganglion Explant as a Method of Studying Neurotrophic Factors in Regenerative Medicine

Biomedicines, 2020
Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of ...
Polina Klimovich, Kseniya Rubina, Veronika Sysoeva, Ekaterina Semina   +3 more
doaj   +1 more source

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

, 2021
RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase function.
Annabel Borg (9332051), Svend Kjær (9181919), Aaron J Borg (8265507), Francesca M Houghton (11165451), Sarah E Adams (11165445), Andrew G Purkiss (8117213), Phillip P Knowles (9331985), David C Briggs (9556640), Andrea Nans (5176226), Christopher P Earl (9622343), Kerry M Goodman (11165448), Pauline B McIntosh (9248357), Agata Nawrotek (4433671), Neil Q McDonald (8118887)   +13 more
core  

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Expression and function of GDNF family ligands and their receptors by human immune cells [PDF]

, 2004
GDNF (glial cell line-derived neurotrophic factor) und NTN (Neurturin), die zwei zuerst beschriebenen Liganden der GDNF-Familie, fungieren als Überlebens- und Entwicklungsfaktoren für definierte Populationen von zentralen und peripheren Neuronen.
Vargas-Leal, V., Vargas, Vivian, Vargas-Leal, Vivian   +2 more
core  

Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

Neurobiology of Disease, 2009
In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astrocytes
Jagdeep K. Sandhu, Mossa Gardaneh, Rafal Iwasiow, Patricia Lanthier, Sandhya Gangaraju, Maria Ribecco-Lutkiewicz, Roger Tremblay, Kazutoshi Kiuchi, Marianna Sikorska   +8 more
doaj   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Identification of mesencephalic neural stem cells overexpressing GDNF (GDNF-mNCSs).

, 2013
(A) Fluorescence photomicrographs show that all neurospheres were immunoreactive for the NSCs marker nestin. The neurospheres of peGFPN1-GDNF-transfected mNSCs (termed GDNF-mNSCs) were strong immunopositive for GDNF compare to mNSCs transfected with ...
Deqiang Lei (492095), Zhongtang Feng (492096), Ru’en Liu (492092), Xiaobin Song (492094), Jiang Long (441275), Xingli Deng (492090), Yuanxin Liang (492091), Hua Lu (240206), Yu Li (183836), Zhiyong Yang (11266), Jinkun Wang (492093)   +10 more
core   +1 more source