Results 51 to 60 of about 34,905 (242)
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Glial cell line-derived neurotrophic factor effects on dental pulp cells and osteoblast-like cells [PDF]
, 2012 Glial cell line-derived neurotrophic factor (GDNF) is a growth factor promoting survival, proliferation and differentiation of neural crest cells. Neural crest cells play an important role within mesenchymal tissues during dental pulp and calvarial bone ...
Gale, Zoe
core
Scientific Reports, 2018 Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD).
Kärt Mätlik +4 more
doaj +1 more source
Neurobiology of Disease, 2009 Inflammation, phospho-p38 MAPK activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson's disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month-old
Heather A. Boger +3 more
doaj +1 more source
Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Clinical Pharmacology &Therapeutics, EarlyView.Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
The effect of high intensity interval swimming training on Glial cell line-derived neurotrophic factor and Rearranged during transfection (RET) gene expression in hippocampal tissue in rats with reserpine induced-Parkinson's disease [PDF]
فیزیولوژی ورزش و فعالیت بدنیBackground and Purpose: Parkinson’s disease is a progressive neurological disorder, where loss of dopamine neurons in the substantia nigra and dopamine depletion in the striatum cause characteristic motor and nonmotor symptoms.
Sahar Abdolahi +3 more
doaj +1 more source
Cellular Localization of gdnf in Adult Zebrafish Brain
Brain Sciences, 2020 Glial cell line-derived neurotrophic factor (GDNF) was initially described as important for dopaminergic neuronal survival and is involved in many other essential functions in the central nervous system.
Chee Ern David Wong +5 more
doaj +1 more source
TAT-GDNF in Neurodegeneration and Ischemic Stroke [PDF]
CNS Drug Reviews, 2006 The delivery of proteins across the blood-brain barrier is severely limited by their size and biochemical properties. Numerous peptides have been characterized in recent years that prevent neuronal death in vitro, but cannot be used therapeutically, since they do not cross cell membrane barriers.
Kilic E, Kilic U, Hermann DM
openaire +3 more sources