Results 61 to 70 of about 34,905 (242)

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Dose dependent expression of GDNF in nerve segments transduced with increasing amounts of LV-GDNF.

, 2013
One centimeter segments of the sciatic nerve were injected with increasing amounts of LV-GDNF ranging from 0.25–2×106 transducing units (TU) and cultured for 10 days.
Martijn R. Tannemaat (444803), Joost Verhaagen (55754), Fred de Winter (444800), Kasper C. D. Roet (444802), Ruben Eggers (55747), Stefan A. Hoyng (444801), Erich M. Ehlert (389273), Martijn J. A. Malessy (126383)   +7 more
core   +1 more source

GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat

Stem Cells International, 2016
Multiple sclerosis (MS) is an autoimmune disease in the CNS. The current immunomodulating drugs for MS do not effectively prevent the progressive neurological decline.
Xiaoqing Gao, Li Deng, Yun Wang, Ling Yin, Chaoxian Yang, Jie Du, Qionglan Yuan   +6 more
doaj   +1 more source

Effect of SkQ1 Antioxidant on Structural and Functional Conditions of The Brain in PostResuscitation Period

Общая реаниматология, 2016
The aim was to assess the efficacy of mitochondriatargeted antioxidant SkQ1 in prevention of structural and functional abnormalities of brain postresuscitation after cardiac arrest.Materials and methods.
M. L. Lovat, M. Sh. Avrushchenko, O. A. Averina, V. V. Pavshintsev, I. V. Ostrova, Y. V. Zarzhetsky, V. V. Moroz, M. V. Egorov   +7 more
doaj   +1 more source

Low‐Concentration Dopamine Potentiates Gastric Motility Through Activation of Dopamine D5 Receptor on Enteric Cholinergic Neurons

Gut Medicine, EarlyView.
ABSTRACT Background Dopamine (DA) exerts complex concentration‐dependent effects on gastrointestinal motility. Although its inhibitory action through D2‐like receptors is well‐established, the mechanisms underlying its excitatory effects remain elusive.
Xiao‐Li Zhang, Tuo Ji, Yue Zhang, Cai‐Feng Zhang, Yun‐Jing Bai, Jin Song   +5 more
wiley   +1 more source

GDNF is required for neural colonization of the pancreas [PDF]

Development, 2013
The mammalian pancreas is densely innervated by both the sympathetic and parasympathetic nervous systems, which control exocrine and endocrine secretion. During embryonic development, neural crest cells migrating in a rostrocaudal direction populate the gut, giving rise to neural progenitor cells.
Muñoz-Bravo, Miguel, Hidalgo Figueroa, María, Pascual Bravo, Alberto, López-Barneo, José, Leal Cerro, Alfonso, Cano González, David A.   +5 more
openaire   +3 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Exploring the diversity of biological processes regulated by glial cell line-derived neurotrophic factor, a pleiotropic molecule with therapeutic potential

Frontiers in Physiology
Glial cell line–derived neurotrophic factor (GDNF) is a potent trophic factor essential for neuronal survival and function. Encoded by the GDNF gene, its mature protein arises from specific post-translational modifications and is secreted through ...
Cristina Porcari, Cristina Porcari, Stefano Cattaneo, Lucia Crippa, Michele Simonato, Michele Simonato, Barbara Bettegazzi, Barbara Bettegazzi   +7 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Endogeeninen GDNF keskiaivojen dopamiinihermosolujen säätelijänä [PDF]

, 2016
Midbrain dopamine neurons exert a powerful influence on behavior and their dysfunction is associated with many neurological and neuropsychiatric diseases, including Parkinson s disease (PD). Dopamine neurons are large, complex and sensitive cells. Hence,
Kopra, Jaakko
core