Results 71 to 80 of about 37,648 (242)

Functional Analysis of Zebrafish GDNF

Developmental Biology, 2001
We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have identified areas of correlated ...
Shepherd, Iain T., Beattie, Christine E., Raible, David W.   +2 more
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM)

, 2013
Glial cell line-derived neurotrophic factor (GDNF) increases survival and neurite extension of spiral ganglion neurons (SGNs), the primary neurons of the auditory system, via yet unknown signaling mechanisms. In other cell types, signaling is achieved by
Schachner, Melitta, Loers, Gabriele, Yang, Kuo H, Pak, Kwang, Leichtle, Anke, Ryan, Allen F, Olshansky, Adel, Euteneuer, Sara, Chavez, Eduardo, Leichtle, Alexander Benedikt   +9 more
core   +1 more source

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

U251 cell migration was promoted by GDNF.

, 2019
(A) The effect of GDNF on U251 cell migration was assessed by wound healing assay ...
Xin-Feng Liu (6274157), Dian-Shuai Gao (6274163), Yue Wang (65477), Jie Wang (16762), Lin-Yan Huang (6274160), Lan Luan (3586568), Lin Zhang (8926), Chuan-Xi Tang (6274154), Dan Wang (34472), Ye Xiong (625227)   +9 more
core   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Dose dependent expression of GDNF in nerve segments transduced with increasing amounts of LV-GDNF.

, 2013
One centimeter segments of the sciatic nerve were injected with increasing amounts of LV-GDNF ranging from 0.25–2×106 transducing units (TU) and cultured for 10 days.
Martijn R. Tannemaat (444803), Joost Verhaagen (55754), Fred de Winter (444800), Kasper C. D. Roet (444802), Ruben Eggers (55747), Stefan A. Hoyng (444801), Erich M. Ehlert (389273), Martijn J. A. Malessy (126383)   +7 more
core   +1 more source

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

, 2023
Glial-cell line derived neurotrophic factor (GDNF) bound to its co-receptor GFRα1 stimulates the RET receptor tyrosine kinase, promoting neuronal survival and neuroprotection.
AG Purkiss (17462412), DC Briggs (17462415), SE Adams (17462403), L Masino (17462409), F Ledda (17462418), FM Houghton (17462400), AS Ríos (17462406), NQ McDonald (17462421)   +7 more
core   +1 more source

Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery

Frontiers in Cellular Neuroscience, 2018
Microglial cells are known as important mediators of inflammation and immune response in the central nervous system (CNS). However, a neuroprotective role of these cells in post-traumatic processes should not be overlooked. Microglial cells are the first
Elvira R. Akhmetzyanova, Yana O. Mukhamedshina, Yana O. Mukhamedshina, Margarita N. Zhuravleva, Luisa R. Galieva, Alexander A. Kostennikov, Ekaterina E. Garanina, Albert A. Rizvanov   +7 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source