Results 91 to 100 of about 37,648 (242)

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation

Summary: Enteroendocrine cells (EECs) differentiate and mature to form functionally distinct populations upon migration along the intestinal crypt-villus axis, but how niche signals affect this process is poorly understood.
Nalle Pentinmikko, Pekka Päivinen, Lemmetyinen, TT, Virtanen, HT, Wartiovaara, L, Timothy C. Wang, Linnea Wartiovaara, Wang, TC, Toni T. Lemmetyinen, Pekka Katajisto, Katajisto, P,, Saara Ollila, Emma W. Viitala, Jaan-Olle Andressoo, Tomi P. Mäkelä, Heikki T. Virtanen, Makela, TP, Paivinen, P, Viitala, EW, Pentinmikko, N, Andressoo, J-O, Ollila, Saara, Katajisto, Pekka, Lemmetyinen, Toni T., Virtanen, Heikki T., Wang, Timothy C., Pentinmikko, Nalle, Mäkelä, Tomi P., Wartiovaara, Linnea, Andressoo, Jaan-Olle, Päivinen, Pekka, Viitala, Emma W.   +31 more
core   +1 more source

The porcine carotid body: morphological and lectin histochemical characterization

Frontiers in Veterinary Science
Although the carotid body (CB) has been widely examined in many animal species, its histological features in pigs have received comparatively little attention.
Ecaterina Semzenisi, Andrei Ungur, Mihai-Cristian Feher, Alexia-Teodora Hoţa, Dragoṣ Hodor, Romelia Pop, Alexandru-Flaviu Tăbăran   +6 more
doaj   +1 more source

A possible role of GDNF expression by which cabergoline use affects corpus callosum

Journal of Pediatric and Neonatal Individualized Medicine, 2018
A variety of malformations have been associated with cabergoline use during gestation. Recently we had a preterm male infant referred to our Neonatal Intensive Care Unit diagnosed with corpus callosum agenesis confirmed by brain ultrasound and brain ...
Georgios Mitsiakos, Anastasia Gkampeta
doaj   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma [PDF]

Glioblastoma is the most common primary brain tumor in adults, characterized by an inherent aggressivity and resistance to treatment leading to poor prognoses.
Burton, Mark, Kristensen, Ida H., Mads Thomassen, Kristensen, Bjarne W., Jérémy Ariey-Bonnet, Ewald, Jesper D., Mark Burton, Bjarne W. Kristensen, Avenel, Inès C.N., Ariey-Bonnet, Jérémy, Jesper D. Ewald, Thesbjerg, Martin N., Michaelsen, Signe R., Ewald, Jesper D.; id_orcid, Signe R. Michaelsen, Inès C. N. Avenel, Ida H. Kristensen, Wennerberg, Krister, Petterson, Stine A., Burton, Mark; id_orcid, Stine A. Petterson, Krister Wennerberg, Martin N. Thesbjerg, Thomassen, Mads   +23 more
core   +1 more source

Immunohistochemical expression of GDNF, p53 and Ki67 with TUNEL assay in canine non-neoplastic esophageal nodules induced by Spirocerca lupi

Macedonian Veterinary Review
Spirocercosis caused by Spirocerca lupi has a global distribution and mainly infects dogs although other carnivores may be affected as well. The research aimed to ascertain the proportion of cellular proliferation/apoptosis within the parasiteinduced ...
Sara Amoorahim, Amir Amniattalab
doaj   +1 more source

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice

Neurobiology of Disease, 2009
Inflammation, phospho-p38 MAPK activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson's disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month-old
Heather A. Boger, Lawrence D. Middaugh, Ann-Charlotte Granholm, Jacqueline F. McGinty   +3 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source