Results 1 to 10 of about 122,423 (305)
Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease [PDF]
Cells, 2021 Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson’
Gian-Carlo Eyer +5 more
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Disinhibition Bursting of Dopaminergic Neurons [PDF]
Frontiers in Systems Neuroscience, 2011 Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in ...
Lobb, Collin J. +3 more
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Selective vulnerability of dopaminergic neurons in Parkinson’s disease connects PRKN and differential expression of CHCHD2 and GPNMB [PDF]
Cell Death and DiseaseThe mechanism(s) causing selective vulnerability of dopaminergic neurons in Parkinson’s disease (PD) remain largely elusive. To improve our understanding of mitochondrial involvement and related pathways suggested to play a role in this selective ...
Franca Vulinovic +8 more
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Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons [PDF]
Molecular BrainMitochondrial dysfunction and abnormalities in mitochondrial quality control contribute to the development of neurodegenerative diseases. Parkinson’s disease is a neurodegenerative disease that causes motor problems mainly due to the loss of dopaminergic
Akihiko Nishijima +8 more
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Stem Cell Reports, 2018 Summary: Neuronal subtype is largely fixed in the adult mammalian brain. Here, however, we unexpectedly reveal that adult mouse striatal neurons can be reprogrammed into dopaminergic neuron-like cells (iDALs). This in vivo phenotypic reprogramming can be
Wenze Niu +4 more
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Proteomic insights into the biology of dopaminergic neurons. [PDF]
Front Mol NeurosciDopaminergic neurons, primarily located in the substantia nigra, hypothalamus, and ventral tegmental area of the brain, play crucial roles in motor control, reward, motivation, and cognition. Alterations in their function are associated with numerous neurological and psychiatric disorders, such as Parkinson’s disease, but also Schizophrenia, substance ...
Cavarischia-Rega C +3 more
europepmc +4 more sources
Molecular Brain, 2021 Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial ...
Mutsumi Yokota +7 more
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PLoS ONE, 2022 Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other brain areas ...
Predrag Jovanovic +7 more
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Analytical Cellular Pathology, 2021 An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu +7 more
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Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes
Frontiers in Physiology, 2022 Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved modulator of numerous aspects of neural functions. Serotonergic neurons in the dorsal and median raphe nucleus provide ascending innervation to the entire forebrain and midbrain ...
Toshiyuki Fujita +6 more
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