Results 11 to 20 of about 598,888 (295)
Disinhibition Bursting of Dopaminergic Neurons [PDF]
Frontiers in Systems Neuroscience, 2011 Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in ...
Lobb, Collin J. +3 more
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Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons [PDF]
Scientific Reports, 2017 AbstractDuring development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. However, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. We previously showed that paired-cultivation of mesencephalic cells containing dopaminergic neurons with striatal ...
Izumi, Yasuhiko +5 more
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Noradrenergic Modulation on Dopaminergic Neurons
Neurotoxicity Research, 2018 It is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (LC-NE) system on dopamine transmission. The disturbance of this modulation may contribute to neurodegeneration of dopaminergic neurons in Parkinson's ...
Meng-Yang Zhu, Zhu, Meng Yang
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CellsDopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald +6 more
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Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons [PDF]
Frontiers in Neural Circuits, 2018 The dopaminergic neurons of the ventral tegmental area (VTA) have been identified with the ability to co-release dopamine and glutamate. This ability was first documented in the nucleus accumbens but showed to be absent in the dorsal striatum.
José Luis Pérez-López +3 more
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Cortical and subcortical somatosensory regulation of dopaminergic neurons: role of the superior colliculus [PDF]
, 2011 Dopaminergic (DA) neurons exhibit a short-latency, phasic response to unexpected biologically salient stimuli, including rewards. Despite extensive research on this DA signal, very little is known about the sources of sensory ...
Bertram, Craig
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Differentiation of Human Pluripotent Cell-derived Neural Rosettes to Dopaminergic Neurons by Small Molecules [PDF]
, 2023 A major challenge for regenerative medicine is differentiation of pluripotent cells to one of the hundreds of specialized cell types in the human body, without the introduction of animal traits or pathogens that would make them useless for ...
Andrei , Kochegarov +4 more
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Dopaminergic regulation of orexin neurons [PDF]
European Journal of Neuroscience, 2005 AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael +5 more
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Cell Death and Disease, 2021 Parkinson’s disease is a common neurodegenerative disease. Cell transplantation is a promising therapeutic option for improving the survival and function of dopaminergic neurons, but the mechanisms underlying the interaction between the transplanted ...
Chengxiao Ma +6 more
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Primary Culture of Mouse Dopaminergic Neurons [PDF]
Journal of Visualized Experiments, 2014 Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory. Nigrostriatal dopaminergic neurons selectively degenerate in Parkinson's disease (PD).
Gaven, Florence +2 more
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