Results 11 to 20 of about 122,423 (305)
PLoS ONE, 2011 Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis +5 more
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CellsDopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald +6 more
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Physiological characterisation of human iPS-derived dopaminergic neurons.
PLoS ONE, 2014 Human induced pluripotent stem cells (hiPSCs) offer the potential to study otherwise inaccessible cell types. Critical to this is the directed differentiation of hiPSCs into functional cell lineages.
Elizabeth M Hartfield +6 more
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Necrostatin-1 protection of dopaminergic neurons
Neural Regeneration Research, 2015 Necroptosis is characterized by programmed necrotic cell death and autophagic activation and might be involved in the death process of dopaminergic neurons in Parkinson's disease. We hypothesized that necrostatin-1 could block necroptosis and give protection to dopaminergic neurons.
Jing-ru Wu +6 more
openaire +4 more sources
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model [PDF]
npj Parkinson's DiseaseThe differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (SNc) is a critical and unresolved question in Parkinson´s disease.
Natalia López-González del Rey +10 more
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Frontiers in Neural Circuits, 2021 Dopamine is an important chemical messenger in the brain, which modulates movement, reward, motivation, and memory. Different populations of neurons can produce and release dopamine in the brain and regulate different behaviors.
Kathleen Carmichael +9 more
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, 2023 A major challenge for regenerative medicine is differentiation of pluripotent cells to one of the hundreds of specialized cell types in the human body, without the introduction of animal traits or pathogens that would make them useless for ...
Andrei , Kochegarov +4 more
core +1 more source
Dopaminergic regulation of orexin neurons [PDF]
European Journal of Neuroscience, 2005 AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael +5 more
openaire +3 more sources
Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]
, 2014 Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
Masoudi, Neda +19 more
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Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice
Molecular Brain, 2020 Aging-related dopaminergic neuronal loss and its motor phenotypes are well known. Excessive loss of dopaminergic neurons leads to Parkinson’s disease (PD), the most common neurodegenerative disorder characterized by the loss of nigrostriatal dopamine ...
Sachiko Noda +4 more
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